Signaling from the epidermal growth factor receptor (EGFR) elicits multiple biological responses, including cell proliferation, migration, and survival. Receptor endocytosis and trafficking are critical physiological processes that control the strength, duration, diversification, and spatial restriction of EGFR signaling through multiple mechanisms, which we review in this chapter. These mechanisms include: (i) regulation of receptor density and activation at the cell surface; (ii) concentration of receptors into distinct nascent endocytic structures; (iii) commitment of the receptor to different endocytic routes; (iv) endosomal sorting and postendocytic trafficking of the receptor through distinct pathways, and (v) recycling to restricted regions of the cell surface. We also highlight how communication between organelles controls EGFR activity along the endocytic route. Finally, we illustrate how abnormal trafficking of EGFR oncogenic mutants, as well as alterations of the endocytic machinery, contributes to aberrant EGFR signaling in cancer.

EGFR Trafficking in Physiology and Cancer / G. Caldieri, M.G. Malabarba, P.P. Di Fiore, S. Sigismund (PROGRESS IN MOLECULAR AND SUBCELLULAR BIOLOGY). - In: Endocytosis and Signaling / [a cura di] C. Lamaze, I. Prior. - [s.l] : Springer, 2018. - ISBN 9783319967035. - pp. 235-272 [10.1007/978-3-319-96704-2_9]

EGFR Trafficking in Physiology and Cancer

G. Caldieri
Primo
;
M.G. Malabarba;P.P. Di Fiore;S. Sigismund
2018

Abstract

Signaling from the epidermal growth factor receptor (EGFR) elicits multiple biological responses, including cell proliferation, migration, and survival. Receptor endocytosis and trafficking are critical physiological processes that control the strength, duration, diversification, and spatial restriction of EGFR signaling through multiple mechanisms, which we review in this chapter. These mechanisms include: (i) regulation of receptor density and activation at the cell surface; (ii) concentration of receptors into distinct nascent endocytic structures; (iii) commitment of the receptor to different endocytic routes; (iv) endosomal sorting and postendocytic trafficking of the receptor through distinct pathways, and (v) recycling to restricted regions of the cell surface. We also highlight how communication between organelles controls EGFR activity along the endocytic route. Finally, we illustrate how abnormal trafficking of EGFR oncogenic mutants, as well as alterations of the endocytic machinery, contributes to aberrant EGFR signaling in cancer.
Settore BIO/13 - Biologia Applicata
2018
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/601122
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