Halogen bonding is nowadays a consolidated tool in chemistry. Only recently, the importance of halogen bonding has been demonstrated also in biological systems, owing to the presence of halogens in drugs. This interaction is due to the anisotropy of the electron density around the halogen that leads to the formation of the ‘σ-hole’, which is responsible for the interaction with a nucleophile site. Unfortunately, classical force fields used in the study of ligand-receptor systems are not able to describe the ‘σ-hole’. Here, we propose a pseudo-atom based methodology able to correctly describe halogen bonding involving chlorine using classical force field.

Halogen bonding in the framework of classical force fields: The case of chlorine / D. Franchini, F. Dapiaggi, S. Pieraccini, A. Forni, M. Sironi. - In: CHEMICAL PHYSICS LETTERS. - ISSN 0009-2614. - 712(2018 Nov 16), pp. 89-94. [10.1016/j.cplett.2018.09.052]

Halogen bonding in the framework of classical force fields: The case of chlorine

D. Franchini
Primo
;
F. Dapiaggi;S. Pieraccini
;
M. Sironi
Ultimo
2018

Abstract

Halogen bonding is nowadays a consolidated tool in chemistry. Only recently, the importance of halogen bonding has been demonstrated also in biological systems, owing to the presence of halogens in drugs. This interaction is due to the anisotropy of the electron density around the halogen that leads to the formation of the ‘σ-hole’, which is responsible for the interaction with a nucleophile site. Unfortunately, classical force fields used in the study of ligand-receptor systems are not able to describe the ‘σ-hole’. Here, we propose a pseudo-atom based methodology able to correctly describe halogen bonding involving chlorine using classical force field.
Physics and Astronomy (all); Physical and Theoretical Chemistry
Settore CHIM/02 - Chimica Fisica
16-nov-2018
set-2018
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/596796
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