Drug induced exfoliative dermatitis (ED) are a group of rare and severe drug hypersensitivity reactions (DHR) involving skin and usually occurring from days to several weeks after drug exposure. Erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the main clinical presentations of drug induced ED. Overall, T cells are the central player of these immune-mediated drug reactions. Here we provide a systematic review on frequency, risk factors, pathogenesis, clinical features and management of patients with drug induced ED.
Drug induced exfoliative dermatitis: State of the art / M. Yacoub, A. Berti, C. Campochiaro, E. Tombetti, G. Ramirez, A. Nico, E. Di Leo, P. Fantini, M. Sabbadini, E. Nettis, G. Colombo. - In: CLINICAL AND MOLECULAR ALLERGY. - ISSN 1476-7961. - 14:1(2016), pp. 9.1-9.12.
Titolo: | Drug induced exfoliative dermatitis: State of the art |
Autori: | |
Parole Chiave: | Clinical features; Delayed type hypersensitivity; Drug hypersensitivity; Erythema multiforme; Exfoliative dermatitis; Lyell’s syndrome; Pathogenesis; Stevens–Johnson syndrome; Therapy; Toxic epidermal necrolysis |
Settore Scientifico Disciplinare: | Settore MED/09 - Medicina Interna |
Data di pubblicazione: | 2016 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1186/s12948-016-0045-0 |
Appare nelle tipologie: | 01 - Articolo su periodico |
File in questo prodotto:
File | Descrizione | Tipologia | Licenza | |
---|---|---|---|---|
Drug induced dermatitis-state of the art- 2016.pdf | Publisher's version/PDF | Open Access Visualizza/Apri |