Drug induced exfoliative dermatitis (ED) are a group of rare and severe drug hypersensitivity reactions (DHR) involving skin and usually occurring from days to several weeks after drug exposure. Erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the main clinical presentations of drug induced ED. Overall, T cells are the central player of these immune-mediated drug reactions. Here we provide a systematic review on frequency, risk factors, pathogenesis, clinical features and management of patients with drug induced ED.
Drug induced exfoliative dermatitis: State of the art / M. Yacoub, A. Berti, C. Campochiaro, E. Tombetti, G. Ramirez, A. Nico, E. Di Leo, P. Fantini, M. Sabbadini, E. Nettis, G. Colombo. - In: CLINICAL AND MOLECULAR ALLERGY. - ISSN 1476-7961. - 14:1(2016), pp. 9.1-9.12. [10.1186/s12948-016-0045-0]
Drug induced exfoliative dermatitis: State of the art
E. Tombetti;
2016
Abstract
Drug induced exfoliative dermatitis (ED) are a group of rare and severe drug hypersensitivity reactions (DHR) involving skin and usually occurring from days to several weeks after drug exposure. Erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the main clinical presentations of drug induced ED. Overall, T cells are the central player of these immune-mediated drug reactions. Here we provide a systematic review on frequency, risk factors, pathogenesis, clinical features and management of patients with drug induced ED.
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