Modulating oxidative stresses and inflammation can potentially prevent or alleviate the pathological conditions of diseases associated with the nervous system, including ischemic optic neuropathy. In this study we evaluated the anti-neuroinflammatory and neuroprotective activities of Rhus coriaria (R. coriaria) extract in vivo. The half maximal inhibitory concentration (IC50) for DPPH, ABTS and β-carotene were 6.79 ± 0.009 μg/mL, 10.94 ± 0.09 μg/mL, and 6.25 ± 0.06 μg/mL, respectively. Retinal ischemia was induced by optic nerve crush injury in albino Balb/c mice. The anti-inflammatory activity of ethanolic extract of R. coriaria (ERC) and linoleic acid (LA) on ocular ischemia was monitored using Fluorescence Molecular Tomography (FMT). Following optic nerve crush injury, the mice treated with 400 mg/kg of ERC and LA exhibited an 84.87% and 86.71% reduction of fluorescent signal (cathepsin activity) respectively. The results of this study provide strong scientific evidence for the neuroprotective activity of the ERC, identifying LA as one of the main components responsible for the effect. ERC may be useful and worthy of further development for its adjunctive utilization in the treatment of optic neuropathy.

Neuroprotective and anti-inflammatory effects of Rhus coriaria extract in a mouse model of ischemic optic neuropathy / S. Khalilpour, G. Behnammanesh, F. Suede, M.O. Ezzat, J. Muniandy, Y. Tabana, M.B.K. Ahamed, A. Tamayol, A.M.S. Majid, E. Sangiovanni, M. Dell'Agli, A.S. Majid. - In: BIOMEDICINES. - ISSN 2227-9059. - 6:2(2018 Jun). [10.3390/biomedicines6020048]

Neuroprotective and anti-inflammatory effects of Rhus coriaria extract in a mouse model of ischemic optic neuropathy

S. Khalilpour
Primo
;
E. Sangiovanni;M. Dell'Agli
Penultimo
;
2018

Abstract

Modulating oxidative stresses and inflammation can potentially prevent or alleviate the pathological conditions of diseases associated with the nervous system, including ischemic optic neuropathy. In this study we evaluated the anti-neuroinflammatory and neuroprotective activities of Rhus coriaria (R. coriaria) extract in vivo. The half maximal inhibitory concentration (IC50) for DPPH, ABTS and β-carotene were 6.79 ± 0.009 μg/mL, 10.94 ± 0.09 μg/mL, and 6.25 ± 0.06 μg/mL, respectively. Retinal ischemia was induced by optic nerve crush injury in albino Balb/c mice. The anti-inflammatory activity of ethanolic extract of R. coriaria (ERC) and linoleic acid (LA) on ocular ischemia was monitored using Fluorescence Molecular Tomography (FMT). Following optic nerve crush injury, the mice treated with 400 mg/kg of ERC and LA exhibited an 84.87% and 86.71% reduction of fluorescent signal (cathepsin activity) respectively. The results of this study provide strong scientific evidence for the neuroprotective activity of the ERC, identifying LA as one of the main components responsible for the effect. ERC may be useful and worthy of further development for its adjunctive utilization in the treatment of optic neuropathy.
Anti-neuroinflammation; Ischemic optic neuropathy; Linoleic acid; Neuroprotection; Rhus coriaria; Medicine (miscellaneous); Biochemistry, Genetics and Molecular Biology (all)
Settore BIO/14 - Farmacologia
23-apr-2018
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/588671
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