Background: Endothelial dysfunction and inflammation are present in both type 2 diabetes mellitus (T2DM) and obesity. In this paper we compared the role of weight loss and of glycaemic control in determining circulating levels of ICAM-1, endothelin-1 (ET-1), and E-selectin in patients with morbid (grade 3) obesity. Methods and Results: ICAM-1, E-selectin, and ET-1 were higher in obese patients (n = 96) than in lean controls (n = 30); among obese patients, the three molecules were higher in T2DM patients (n = 26) than in patients with normal (NGT, n = 43) or impaired (IGT, n = 27) glucose tolerance. Sixty-eight obese patients had a significant weight loss induced by bariatric surgery, and showed a significant decrease in blood glucose, HbA1c and all molecules, so that ICAM-1, E-selectin, and ET-1 were not different in NGT, IGT and T2DM patients, and in lean controls; in 13 patients with a small weight loss induced by diet, changes were not significant, in spite of a significant reduction in blood glucose and HbA1c. At stepwise regression, changes in ICAM-1, ET-1, and E-selectin significantly correlated only with change in body mass index. Conclusions: These data indicate that weight loss is more important than glycaemic control in regulating circulating levels of ICAM-1, ET-1, E-selectin in morbidly obese subjects.
Body weight and glucose metabolism have a different effect on circulating levels of ICAM-1, E-selectin, and endothelin-1 in humans / A.E. Pontiroli, P. Pizzocri, D. Koprivec, P. Vedani, M. Marchi, C. Arcelloni, R. Paroni, K. Esposito, D. Giugliano. - In: EUROPEAN JOURNAL OF ENDOCRINOLOGY. - ISSN 0804-4643. - 150:2(2004), pp. 195-200.
|Titolo:||Body weight and glucose metabolism have a different effect on circulating levels of ICAM-1, E-selectin, and endothelin-1 in humans|
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
Settore MED/09 - Medicina Interna
|Data di pubblicazione:||2004|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1530/eje.0.1500195|
|Appare nelle tipologie:||01 - Articolo su periodico|