Objective A 6-minute walk work (6MWW), that is the product of distance walked at the 6-minute walk test (6MWT) multiplied by body weight, has been suggested as an appropriate variable for estimating functional capacity. Under the hypothesis that 6MWW strongly correlates with expiratory muscle strength (P(E)max), as found in Chronic Obstructive Pulmonary Disease (COPD), the aim of the study was to determine the degree of this correlation in adults with cystic fibrosis. MethodsResultsA cross-sectional study was carried out at the Regional Referral Centre for Cystic Fibrosis, where patients with cystic fibrosis attending their regular follow-up, aged 18years or older with mild-to-normal lung disease, were asked to participate. Dietitians determined nutritional status before subjects performed spirometry and static measurement of respiratory muscles. The 6MWT was performed as the last study procedure. Spearman correlation test was used to correlate P(E)max with 6MWW and other study variables. Twenty-five cystic fibrosis subjects aged 18-30years and with FEV1 values ranging from 42.4% to 123.4% predicted completed the study. P(E)max strongly correlated with 6MWW (rho .72, p=.0001) whereas it did not correlate with other study variables, including distance at the 6MWT. Distance walked multiplied by body weight (p=.0019) and body mass index (p=.0238) were significantly lower in those with P(E)max below the lower limits of normal. ConclusionIncreased functional exercise tolerance is related to higher static expiratory pressure in patients with mild-to-normal cystic fibrosis lung disease. Difference in exercise performance might reflect a possible difference in body composition that needs to be further investigated.

Expiratory muscle strength and functional exercise tolerance in adults with cystic fibrosis: a cross-sectional study / S. Gambazza, V. Turrin, C. Speziali, A. Brivio, L. Valmarana, F. Carta, A.M.C. Bulfamante, C. Colombo. - In: PHYSIOTHERAPY RESEARCH INTERNATIONAL. - ISSN 1358-2267. - 23:4(2018 Oct).

Expiratory muscle strength and functional exercise tolerance in adults with cystic fibrosis: a cross-sectional study

S. Gambazza
Primo
;
L. Valmarana;A.M.C. Bulfamante
Penultimo
;
C. Colombo
Ultimo
2018-10

Abstract

Objective A 6-minute walk work (6MWW), that is the product of distance walked at the 6-minute walk test (6MWT) multiplied by body weight, has been suggested as an appropriate variable for estimating functional capacity. Under the hypothesis that 6MWW strongly correlates with expiratory muscle strength (P(E)max), as found in Chronic Obstructive Pulmonary Disease (COPD), the aim of the study was to determine the degree of this correlation in adults with cystic fibrosis. MethodsResultsA cross-sectional study was carried out at the Regional Referral Centre for Cystic Fibrosis, where patients with cystic fibrosis attending their regular follow-up, aged 18years or older with mild-to-normal lung disease, were asked to participate. Dietitians determined nutritional status before subjects performed spirometry and static measurement of respiratory muscles. The 6MWT was performed as the last study procedure. Spearman correlation test was used to correlate P(E)max with 6MWW and other study variables. Twenty-five cystic fibrosis subjects aged 18-30years and with FEV1 values ranging from 42.4% to 123.4% predicted completed the study. P(E)max strongly correlated with 6MWW (rho .72, p=.0001) whereas it did not correlate with other study variables, including distance at the 6MWT. Distance walked multiplied by body weight (p=.0019) and body mass index (p=.0238) were significantly lower in those with P(E)max below the lower limits of normal. ConclusionIncreased functional exercise tolerance is related to higher static expiratory pressure in patients with mild-to-normal cystic fibrosis lung disease. Difference in exercise performance might reflect a possible difference in body composition that needs to be further investigated.
cystic fibrosis; exercise tolerance; nutrition assessment; respiratory muscle
Settore MED/48 -Scienze Infermie.e Tecniche Neuro-Psichiatriche e Riabilitattive
giu-2018
Article (author)
File in questo prodotto:
File Dimensione Formato  
Gambazza_et_al-2018-Physiotherapy_Research_International.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 184.99 kB
Formato Adobe PDF
184.99 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/580026
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 5
social impact