IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca
IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.
AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.
EnglishThis study aimed to assess the toxicological consequences related to the interaction of fullerene nanoparticles (C60) and Benzo(α)pyrene (B(α)P) on zebrafish embryos, which were exposed to C60and B(α)P alone and to C60doped with B(α)P. The uptake of pollutants into their tissues and intra-cellular localization were investigated by immunofluorescence and electron microscopy. A set of biomarkers of genotoxicity and oxidative stress, as well as functional proteomics analysis were applied to assess the toxic effects due to C60interaction with B(α)P. The carrier role of C60for B(α)P was observed, however adsorption on C60did not affect the accumulation and localization of B(α)P in the embryos. Instead, C60doped with B(α)P resulted more prone to sedimentation and less bioavailable for the embryos compared to C60alone. As for toxicity, our results suggested that C60alone elicited oxidative stress in embryos and a down-regulation of proteins involved in energetic metabolism. The C60+ B(α)P induced cellular response mechanisms similar to B(α)P alone, but generating greater cellular damages in the exposed embryos. Once C60nanoparticles and B(α)P meet in water, they reciprocally affect their bioavailability and, by consequence, their toxicity to organisms.
The interactions of fullerene C60and Benzo(α)pyrene influence their bioavailability and toxicity to zebrafish embryos / C. Della Torre, D. Maggioni, A. Ghilardi, M. Parolini, N. Santo, C. Landi, L. Madaschi, S. Magni, S. Tasselli, M. Ascagni, L. Bini, C. La Porta, L. Del Giacco, A. Binelli. - In: ENVIRONMENTAL POLLUTION. - ISSN 0269-7491. - 241(2018 Oct), pp. 999-1008.
| Titolo: | The interactions of fullerene C60and Benzo(α)pyrene influence their bioavailability and toxicity to zebrafish embryos |
| Autori: | MAGGIONI, DANIELA (Secondo) DEL GIACCO, LUCA PASQUALE CARMELO (Penultimo) BINELLI, ANDREA PAOLO (Ultimo) |
| Parole Chiave: | Danio rerio; Fullerene nanoparticles; oxidative stress; proteomics; Trojan horse effect; toxicology; pollution; health, toxicology and mutagenesis |
| Settore Scientifico Disciplinare: | Settore BIO/07 - Ecologia |
| Progetto: | In vitro and in vivo evaluation of the benzo(a)pyrene contribution to carbon nanoparticle toxicity |
| Data di pubblicazione: | ott-2018 |
| Rivista: | |
| Tipologia: | Article (author) |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.envpol.2018.06.042 |
| Appare nelle tipologie: | 01 - Articolo su periodico |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| ENVPOL_2018_911_Revision 2_V0-2.pdf | Post-print, accepted manuscript ecc. (versione accettata dall'editore) | Open Access Visualizza/Apri | ||
| 1-s2.0-S0269749118309394-main.pdf | Publisher's version/PDF | Administrator Richiedi una copia |
Copyright © 2021