A short and efficient synthesis of cyrmenin B1, an antifungal metabolite of myxobacteria Cystobacter armeniaca and Archangium gephyra, is described. The crucial steps of the synthesis included the formation of the dehydroalanine moiety from the corresponding serine acetate and the formation of the β-methoxyacrylate system via trimethylsilyldiazomethane methylation of the corresponding β-hydroxy enamide
First Total Synthesis of Cyrmenin B1 / N.S. Chakor, L. Musso, S. Dallavalle. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - 74:2(2009), pp. 844-849.
First Total Synthesis of Cyrmenin B1
N.S. ChakorPrimo
;L. MussoSecondo
;S. DallavalleUltimo
2009
Abstract
A short and efficient synthesis of cyrmenin B1, an antifungal metabolite of myxobacteria Cystobacter armeniaca and Archangium gephyra, is described. The crucial steps of the synthesis included the formation of the dehydroalanine moiety from the corresponding serine acetate and the formation of the β-methoxyacrylate system via trimethylsilyldiazomethane methylation of the corresponding β-hydroxy enamide
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