The Rh-catalyzed hydrogenations of dimethyl itaconate and methyl acetamido acrylate using selected heterocombinations of pentafluorobenzyl- and methoxybenzyl-derived binaphthyl phosphites proved to be highly enantioselective (ee 93–99%). In these selected cases the Rh-heterocomplexes, which were formed in a statistical amount (ca. 50% by 31P NMR), turned out to be more active and selective than the two homocomplexes.
Highly enantioselective Rh-catalyzed hydrogenations with heterocombinations of pentafluorobenzyl- and methoxybenzyl-derived binaphthyl phosphites / B. Lynikaite, J. Cvengros, U. Piarulli, C.M.A. Gennari. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 49:5(2008), pp. 755-759.
Highly enantioselective Rh-catalyzed hydrogenations with heterocombinations of pentafluorobenzyl- and methoxybenzyl-derived binaphthyl phosphites
B. LynikaitePrimo
;J. CvengrosSecondo
;C.M.A. GennariUltimo
2008
Abstract
The Rh-catalyzed hydrogenations of dimethyl itaconate and methyl acetamido acrylate using selected heterocombinations of pentafluorobenzyl- and methoxybenzyl-derived binaphthyl phosphites proved to be highly enantioselective (ee 93–99%). In these selected cases the Rh-heterocomplexes, which were formed in a statistical amount (ca. 50% by 31P NMR), turned out to be more active and selective than the two homocomplexes.
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