Autoimmune liver diseases coexist with rheumatic disorders in approximately 30% of cases and may also share pathogenic mechanisms. Autoimmune liver diseases result from an immune-mediated injury of different tissues, with autoimmune hepatitis (AIH) targeting hepatocytes, and primary biliary cholangitis (PBC) and primary sclerosing cholangitis targeting cholangiocytes. Sjogren syndrome is diagnosed in 7% of AIH cases and serologic autoimmunity profiles are a common laboratory abnormality, particularly in the case of serum antimitochondrial (PBC) or anti–liver kidney microsomal antibodies (AIH). Therapeutic strategies may overlap between rheumatic and autoimmune liver diseases and practitioners should be vigilant in managing bone loss.

Rheumatic Manifestations in Autoimmune Liver Disease / C. Selmi, E. Generali, M.E. Gershwin. - In: RHEUMATIC DISEASE CLINICS OF NORTH AMERICA. - ISSN 0889-857X. - 44:1(2018), pp. 65-87. [10.1016/j.rdc.2017.09.008]

Rheumatic Manifestations in Autoimmune Liver Disease

C. Selmi;
2018

Abstract

Autoimmune liver diseases coexist with rheumatic disorders in approximately 30% of cases and may also share pathogenic mechanisms. Autoimmune liver diseases result from an immune-mediated injury of different tissues, with autoimmune hepatitis (AIH) targeting hepatocytes, and primary biliary cholangitis (PBC) and primary sclerosing cholangitis targeting cholangiocytes. Sjogren syndrome is diagnosed in 7% of AIH cases and serologic autoimmunity profiles are a common laboratory abnormality, particularly in the case of serum antimitochondrial (PBC) or anti–liver kidney microsomal antibodies (AIH). Therapeutic strategies may overlap between rheumatic and autoimmune liver diseases and practitioners should be vigilant in managing bone loss.
Immune tolerance; Personalized medicine; Autoimmune comorbidity; Cholangitis; Hepatitis; Osteoporosis; Methotrexate; Autoantibody
Settore MED/16 - Reumatologia
Settore MED/09 - Medicina Interna
2018
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/565949
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