The activities of the heterogeneous Polycomb (PcG) group of proteins ensure that the developmental processes of proliferation and cellular identity establishment are carried out correctly. PcG proteins assemble stable multiprotein complexes that, together with additional factors, maintain their target genes in a transcriptionally repressive state. The biochemical and functional features of PcG proteins have been extensively investigated over the years. Here we analyse the biochemical and mechanistic proprieties of PcG proteins with respect to recent advances that link the genetic alterations of PcG activity to cancer development.

Emerging roles for Polycomb proteins in cancer / D. Pasini, L. Di Croce. - In: CURRENT OPINION IN GENETICS & DEVELOPMENT. - ISSN 0959-437X. - 36(2016), pp. 50-58. [10.1016/j.gde.2016.03.013]

Emerging roles for Polycomb proteins in cancer

D. Pasini;
2016

Abstract

The activities of the heterogeneous Polycomb (PcG) group of proteins ensure that the developmental processes of proliferation and cellular identity establishment are carried out correctly. PcG proteins assemble stable multiprotein complexes that, together with additional factors, maintain their target genes in a transcriptionally repressive state. The biochemical and functional features of PcG proteins have been extensively investigated over the years. Here we analyse the biochemical and mechanistic proprieties of PcG proteins with respect to recent advances that link the genetic alterations of PcG activity to cancer development.
Carcinogenesis; Cell Proliferation; Humans; Multiprotein Complexes; Neoplasms; Polycomb-Group Proteins; Genetics; Developmental Biology
Settore BIO/11 - Biologia Molecolare
Settore BIO/13 - Biologia Applicata
Settore BIO/10 - Biochimica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/562775
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