The activities of the heterogeneous Polycomb (PcG) group of proteins ensure that the developmental processes of proliferation and cellular identity establishment are carried out correctly. PcG proteins assemble stable multiprotein complexes that, together with additional factors, maintain their target genes in a transcriptionally repressive state. The biochemical and functional features of PcG proteins have been extensively investigated over the years. Here we analyse the biochemical and mechanistic proprieties of PcG proteins with respect to recent advances that link the genetic alterations of PcG activity to cancer development.
Emerging roles for Polycomb proteins in cancer / D. Pasini, L. Di Croce. - In: CURRENT OPINION IN GENETICS & DEVELOPMENT. - ISSN 0959-437X. - 36(2016), pp. 50-58. [10.1016/j.gde.2016.03.013]
Emerging roles for Polycomb proteins in cancer
D. Pasini
;
2016
Abstract
The activities of the heterogeneous Polycomb (PcG) group of proteins ensure that the developmental processes of proliferation and cellular identity establishment are carried out correctly. PcG proteins assemble stable multiprotein complexes that, together with additional factors, maintain their target genes in a transcriptionally repressive state. The biochemical and functional features of PcG proteins have been extensively investigated over the years. Here we analyse the biochemical and mechanistic proprieties of PcG proteins with respect to recent advances that link the genetic alterations of PcG activity to cancer development.
| File | Dimensione | Formato | |
|---|---|---|---|
|
1-s2.0-S0959437X16300223-main.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
1.65 MB
Formato
Adobe PDF
|
1.65 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
