G protein-coupled receptor signaling starts at the plasma membrane and continues at endosomal stations. In this issue, Inda et al. (2016. J. Cell Biol. http ://dx .doi .org /10 .1083 /jcb .201512075) show that different forms of adenylyl cyclase are activated at the plasma membrane versus endosomes, providing a rationale for the spatial encoding of cAMP signaling.
Spatial resolution of cAMP signaling by soluble adenylyl cyclase / G. Caldieri, S. Sigismund. - In: THE JOURNAL OF CELL BIOLOGY. - ISSN 0021-9525. - 214:2(2016 Jul 18), pp. 125-127. [10.1083/jcb.201606123]
Spatial resolution of cAMP signaling by soluble adenylyl cyclase
G. Caldieri;S. Sigismund
2016
Abstract
G protein-coupled receptor signaling starts at the plasma membrane and continues at endosomal stations. In this issue, Inda et al. (2016. J. Cell Biol. http ://dx .doi .org /10 .1083 /jcb .201512075) show that different forms of adenylyl cyclase are activated at the plasma membrane versus endosomes, providing a rationale for the spatial encoding of cAMP signaling.
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