Neutrophils are the most abundant white blood cells and are the first recruited to inflammatory sites. Neutrophils are an important component of the tumor stroma and can exert both anti-tumoral and pro-tumoral activities, depending on their maturation and activation state. In human gliomas, the number of circulating and infiltrating neutrophils correlates with the severity of the disease, indicating a prognostic and possible pro-tumoral role for these leukocytes. In glioma preclinical models, neutrophils promote tumor growth and orchestrate the resistance to anti-angiogenic therapies. Nevertheless, recent data indicate that neutrophils can be activated to directly kill tumor cells or to orchestrate the anti-tumoral response. Here, we review current knowledge about the role of neutrophils in glioma and their possible involvement in new strategies to improve current cancer therapies.
Neutrophils in gliomas / M. Massara, P. Persico, O. Bonavita, V. Mollica Poeta, M. Locati, M. Simonelli, R. Bonecchi. - In: FRONTIERS IN IMMUNOLOGY. - ISSN 1664-3224. - 8(2017 Oct 26), pp. 1349.1-1349.7.
|Titolo:||Neutrophils in gliomas|
BONECCHI, RAFFAELLA (Corresponding)
|Parole Chiave:||Cancer immunotherapy; Chemokines; Glioma; Immunotherapy; Inflammation and cancer; Neutrophils; Immunology and Allergy; Immunology|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||26-ott-2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3389/fimmu.2017.01349|
|Appare nelle tipologie:||01 - Articolo su periodico|