Neutrophils are the most abundant white blood cells and are the first recruited to inflammatory sites. Neutrophils are an important component of the tumor stroma and can exert both anti-tumoral and pro-tumoral activities, depending on their maturation and activation state. In human gliomas, the number of circulating and infiltrating neutrophils correlates with the severity of the disease, indicating a prognostic and possible pro-tumoral role for these leukocytes. In glioma preclinical models, neutrophils promote tumor growth and orchestrate the resistance to anti-angiogenic therapies. Nevertheless, recent data indicate that neutrophils can be activated to directly kill tumor cells or to orchestrate the anti-tumoral response. Here, we review current knowledge about the role of neutrophils in glioma and their possible involvement in new strategies to improve current cancer therapies.
Neutrophils in gliomas / M. Massara, P. Persico, O. Bonavita, V. Mollica Poeta, M. Locati, M. Simonelli, R. Bonecchi. - In: FRONTIERS IN IMMUNOLOGY. - ISSN 1664-3224. - 8(2017 Oct 26), pp. 1349.1-1349.7.
Titolo: | Neutrophils in gliomas | |
Autori: | BONECCHI, RAFFAELLA (Corresponding) | |
Parole Chiave: | Cancer immunotherapy; Chemokines; Glioma; Immunotherapy; Inflammation and cancer; Neutrophils; Immunology and Allergy; Immunology | |
Settore Scientifico Disciplinare: | Settore MED/04 - Patologia Generale | |
Data di pubblicazione: | 26-ott-2017 | |
Rivista: | ||
Tipologia: | Article (author) | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.3389/fimmu.2017.01349 | |
Appare nelle tipologie: | 01 - Articolo su periodico |
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