We tested 24 MG patients with thymoma (11 invasive) for the presence of anti-neuronal nicotinic receptor subtype antibodies and found that none had antibodies against the alpha7-containing subtype, and only one (with invasive thymoma) had antibodies directed against the alpha3-containing subtype. In this patient, the anti-alpha3 antibodies recognized the extracellular part of the alpha3 subunit. They developed later than the anti-alpha1 muscle antibodies, with their titer increasing during the illness, while that of the anti-alpha1 muscle antibody decreased. Our data suggest that there is no correlation between the presence of anti-alpha3 antibodies and thymoma.
|Titolo:||Anti-neuronal nicotinic receptor antibodies in MG patients with thymoma|
|Autori interni:||FORNASARI, DIEGO MARIA MICHELE|
|Parole Chiave:||Neuronal nicotinic receptor subtypes ; Thymoma ; Antibodies ; Myasthenia gravis|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||feb-2001|
|Digital Object Identifier (DOI):||10.1016/S0165-5728(00)00416-1|
|Appare nelle tipologie:||01 - Articolo su periodico|