This work describes the organocatalytic α-trifluoromethylthiolation of silylenol ethers using N-(trifluoromethylthio)saccharin as trifluoromethylthiolating reagent that is activated by the presence of catalytic amounts of a Lewis base. Tetrahydrothiophene was identified as the best organocatalyst and it was successfully employed to promote the synthesis of different α-trifluoromethylketones; the reaction has been performed under a traditional batch methodology and under continuous flow conditions. In general, yields obtained using the traditional batch process were higher than those observed when the reaction was performed under flow conditions. However, short reaction times, higher productivity and higher space time yields were observed when a flow system process was employed. Preliminary DFT calculations were also performed in order to elucidate the mechanism of the reaction.

Organocatalytic alpha-trifluoromethylthiolation of silylenol ethers : Batch vs continuous flow reactions / A. Said Said, M. Benaglia, S. Rossi, R.M. Annunziata. - In: CATALYSIS TODAY. - ISSN 0920-5861. - 308(2018 Jun), pp. 94-101. [10.1016/j.cattod.2017.09.013]

Organocatalytic alpha-trifluoromethylthiolation of silylenol ethers : Batch vs continuous flow reactions

M. Benaglia
;
S. Rossi
;
R.M. Annunziata
2018

Abstract

This work describes the organocatalytic α-trifluoromethylthiolation of silylenol ethers using N-(trifluoromethylthio)saccharin as trifluoromethylthiolating reagent that is activated by the presence of catalytic amounts of a Lewis base. Tetrahydrothiophene was identified as the best organocatalyst and it was successfully employed to promote the synthesis of different α-trifluoromethylketones; the reaction has been performed under a traditional batch methodology and under continuous flow conditions. In general, yields obtained using the traditional batch process were higher than those observed when the reaction was performed under flow conditions. However, short reaction times, higher productivity and higher space time yields were observed when a flow system process was employed. Preliminary DFT calculations were also performed in order to elucidate the mechanism of the reaction.
Flow chemistry; Lewis bases; Organocatalysis; Silylenol ether; Trifluoromethylthiolation; Catalysis; Chemistry (all)
Settore CHIM/06 - Chimica Organica
14-set-2017
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/532845
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