Background: Objectives: ElastPQÂ®-pSWE is an ultrasound technique developed to stage disease severity in patients with chronic liver diseases. Little data is available about its application to the pancreas.We aimed to assess the feasibility and reproducibility of pancreatic stiffness (PS) measurements in patients with chronic pancreatitis and their relationship with clinical and laboratory data. Material and methods: 52 consecutive patients with chronic pancreatitis (CP) (40 males; median age 60 years) underwent hepatic and pancreatic pSWE. Liver stiffness was measured by transient elastography, 42 healthy subjects being controls (25 males; median age 54 years). Pancreatic pSWE inter-observer agreement was analyzed by intraclass correlation coefficient (ICC). The effects of clinical, laboratory and US data on PS measurements were evaluated by linear regression. Results: pSWE was feasible in all the CP patients, but one. Pancreatic stiffness was significantly higher in CP patients than healthy controls (4.3 Â± SD 2.4 vs. 2.8 Â± SD 1.1 kPa, respectively, p = 0.001). Significantly higher values in the CP group were observed in patients with longer disease duration (>10 vs. â¤10 years) (5.8 Â± SD 4 vs. 3.9 Â± SD 1.5 kPa, respectively, p = 0.01), on chronic analgesic drugs (6.0 vs. 3.5 kPa, p < 0.05) and with lower body weight (p < 0.05, r = -0.38). At multivariate analysis all the three variables resulted independently associated to the pancreatic stiffness value. The ICC for PS was 0.77. Conclusions: ElastPQÂ®-pSWE is promising and reproducible in assessing pancreatic stiffness, which mainly reflects disease length and severity. Accordingly, its use is of potential value in stratifying CP patients by identifying those with a more serious degree of disease.
Point shear-wave elastography in chronic pancreatitis : A promising tool for staging disease severity / R. Pozzi, I. Parzanese, A. Baccarin, M. Giunta, C.B. Conti, P. Cantu', G. Casazza, A. Tenca, R. Rosa, D. Gridavilla, G. Casella, D. Conte, M. Fraquelli. - In: PANCREATOLOGY. - ISSN 1424-3903. - 17:6(2017 Dec), pp. 905-910.
|Titolo:||Point shear-wave elastography in chronic pancreatitis : A promising tool for staging disease severity|
|Parole Chiave:||ARFI; chronic pancreatitis; elastography; endocrinology, diabetes and metabolism; hepatology; endocrinology|
|Settore Scientifico Disciplinare:||Settore MED/12 - Gastroenterologia|
Settore MED/01 - Statistica Medica
|Data di pubblicazione:||dic-2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.pan.2017.10.003|
|Appare nelle tipologie:||01 - Articolo su periodico|
File in questo prodotto:
|2017 Pancreatology Point shear-wave elastography in chronic pancreatitis.pdf||Publisher's version/PDF||Administrator Richiedi una copia|