In the present study the esterification of the OH groups of resveratrol, caffeic acid, ferulic acid, and -sitosterol with an antioxidant polyconjugated fatty acid, (2E,4E,6E)-octa-2,4,6-trienoic acid, was achieved. As the selective esterification of OH groups of natural compounds can affect their biological activity, a selective esterification of resveratrol and caffeic acid was performed by an enzymatic approach. The new resulting compounds were characterized spectroscopically (FT-IR, NMR mono, and bidimensional techniques); when necessary the experimental data were integrated by quantum chemical calculations. The antioxidant, anti-inflammatory and proliferative activity was evaluated. The good results encourage the use of these molecules as antioxidant and/or anti-inflammatory agents in dermocosmetic application.
Synthesis and biological evaluation of new natural phenolic (2E,4E,6E)-Octa-2,4,6-trienoic esters / R. Gandolfi, A. Contini, D. Pinto, B. Marzani, S. Pandini, D. Nava, E.R.E. Pini. - In: CHEMISTRY & BIODIVERSITY. - ISSN 1612-1872. - 14:12(2017 Dec), pp. e1700294.1-e1700294.14.
|Titolo:||Synthesis and biological evaluation of new natural phenolic (2E,4E,6E)-Octa-2,4,6-trienoic esters|
PINI, ELENA RENATA ELVIRA (Corresponding)
|Parole Chiave:||natural products; selective esterification; biocatalysis; antioxidant activity; anti-inflammatory activity|
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
Settore CHIM/11 - Chimica e Biotecnologia delle Fermentazioni
|Data di pubblicazione:||dic-2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/cbdv.201700294|
|Appare nelle tipologie:||01 - Articolo su periodico|