Objective To investigate the long-term mortality of a cohort of Italian asbestos miners. Methods The cohort included 1056 men employed in a chrysotile mine between 1930 and 1990, who were followed up during 1946-2014, for a total of 37 471 person-years of observation. Expected deaths and SMRs were computed using national and local (after 1980, when available) reference. Results A total of 294 (27.8%) subjects were alive and at the end of follow-up, 722 (68.4%) were dead and 40 (3.8%) were lost to follow-up. The SMR for overall mortality was 1.35 (95%CI 1.25 to 1.45). The SMR for pleural cancer, based on seven observed deaths, was 5.54 (95% CI 2.22 to 11.4) and related to time since first exposure, but not to duration of employment, cumulative exposure or time since last exposure. The SMR for lung cancer was 1.16 (95% CI 0.87 to 1.52; 53 observed deaths), with no excess among workers with cumulative exposure below 100 fibre/mL-years (SMR 0.82; 95% CI 0.44 to 1.40). Conclusions The update of the follow-up of this cohort confirmed an increased mortality from pleural cancer mortality in miners exposed to chrysotile and a lack of significant increase in lung cancer mortality.

Mortality from cancer and other causes among Italian chrysotile asbestos miners / E. Pira, C. Romano, F. Donato, C. Pelucchi, C.L. Vecchia, P. Boffetta. - In: OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. - ISSN 1351-0711. - 74:8(2017 Apr 24), pp. 558-563.

Mortality from cancer and other causes among Italian chrysotile asbestos miners

C. Pelucchi;C.L. Vecchia;
2017

Abstract

Objective To investigate the long-term mortality of a cohort of Italian asbestos miners. Methods The cohort included 1056 men employed in a chrysotile mine between 1930 and 1990, who were followed up during 1946-2014, for a total of 37 471 person-years of observation. Expected deaths and SMRs were computed using national and local (after 1980, when available) reference. Results A total of 294 (27.8%) subjects were alive and at the end of follow-up, 722 (68.4%) were dead and 40 (3.8%) were lost to follow-up. The SMR for overall mortality was 1.35 (95%CI 1.25 to 1.45). The SMR for pleural cancer, based on seven observed deaths, was 5.54 (95% CI 2.22 to 11.4) and related to time since first exposure, but not to duration of employment, cumulative exposure or time since last exposure. The SMR for lung cancer was 1.16 (95% CI 0.87 to 1.52; 53 observed deaths), with no excess among workers with cumulative exposure below 100 fibre/mL-years (SMR 0.82; 95% CI 0.44 to 1.40). Conclusions The update of the follow-up of this cohort confirmed an increased mortality from pleural cancer mortality in miners exposed to chrysotile and a lack of significant increase in lung cancer mortality.
Asbestos; chrysotile; lung cancer; mining; pleural cancer; Aged; Aged, 80 and over; Asbestos, Serpentine; Cause of Death; Chronic Disease; Cohort Studies; Environmental Monitoring; Humans; Italy; Lung Neoplasms; Male; Mesothelioma; Middle Aged; Mining; Mortality; Neoplasms; Occupational Diseases; Occupational Exposure; Pleural Neoplasms; Poisson Distribution; Public Health, Environmental and Occupational Health
Settore MED/01 - Statistica Medica
24-apr-2017
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/524660
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