1,2,3-Triazole is a well-known scaffold that has a widespread occurrence in different compounds characterized by several bioactivities, such as antimicrobial, antiviral, and antitumor effects. Moreover, the structural features of 1,2,3-triazole enable it to mimic different functional groups, justifying its wide use as a bioisostere for the synthesis of new active molecules. Here, we provide an overview of the 1,2,3-triazole ring as a bioisostere for the design of drug analogs, highlighting relevant recent examples.

The 1,2,3-triazole ring as a bioisostere in medicinal chemistry / E. Bonandi, M.S. Christodoulou, G. Fumagalli, D. Perdicchia, G. Rastelli, D. Passarella. - In: DRUG DISCOVERY TODAY. - ISSN 1359-6446. - 22:10(2017 Oct), pp. 1572-1581.

The 1,2,3-triazole ring as a bioisostere in medicinal chemistry

E. Bonandi
Primo
;
M.S. Christodoulou;G. Fumagalli;D. Perdicchia;D. Passarella
2017

Abstract

1,2,3-Triazole is a well-known scaffold that has a widespread occurrence in different compounds characterized by several bioactivities, such as antimicrobial, antiviral, and antitumor effects. Moreover, the structural features of 1,2,3-triazole enable it to mimic different functional groups, justifying its wide use as a bioisostere for the synthesis of new active molecules. Here, we provide an overview of the 1,2,3-triazole ring as a bioisostere for the design of drug analogs, highlighting relevant recent examples.
Pharmacology; Drug Discovery; 3003; Pharmaceutical Science
Settore CHIM/06 - Chimica Organica
Settore CHIM/08 - Chimica Farmaceutica
ott-2017
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/521266
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