1,2,3-Triazole is a well-known scaffold that has a widespread occurrence in different compounds characterized by several bioactivities, such as antimicrobial, antiviral, and antitumor effects. Moreover, the structural features of 1,2,3-triazole enable it to mimic different functional groups, justifying its wide use as a bioisostere for the synthesis of new active molecules. Here, we provide an overview of the 1,2,3-triazole ring as a bioisostere for the design of drug analogs, highlighting relevant recent examples.
The 1,2,3-triazole ring as a bioisostere in medicinal chemistry / E. Bonandi, M.S. Christodoulou, G. Fumagalli, D. Perdicchia, G. Rastelli, D. Passarella. - In: DRUG DISCOVERY TODAY. - ISSN 1359-6446. - 22:10(2017 Oct), pp. 1572-1581.
Titolo: | The 1,2,3-triazole ring as a bioisostere in medicinal chemistry | |
Autori: | BONANDI, ELISA (Primo) PASSARELLA, DANIELE (Corresponding) | |
Parole Chiave: | Pharmacology; Drug Discovery; 3003; Pharmaceutical Science | |
Settore Scientifico Disciplinare: | Settore CHIM/06 - Chimica Organica Settore CHIM/08 - Chimica Farmaceutica | |
Data di pubblicazione: | ott-2017 | |
Rivista: | ||
Tipologia: | Article (author) | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.drudis.2017.05.014 | |
Appare nelle tipologie: | 01 - Articolo su periodico |
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