Signaling from internalized receptors

Activation of many receptors triggers a cascade of signal transducing events and increases their rate of internalization. Receptor endocytosis has always been viewed primarily as a mechanism to negatively regulate receptor activation, but recent evidence suggests that internalization may result in the formation of specialized signaling platforms on intracellular vesicles. Thus, the investigation of the molecular composition of the various vesicular compartments, their interplay and their spatial and temporal regulation is crucial in order to fully understand the modality of cell signaling.