A time specific delayed/pulsatile release dosage form which comprises: a core comprising at least one active principle and at least one disintegrating agent; a sealing layer surrounding the core essentially consisting of one or more water soluble or water insoluble pH independent polymers; an outer coating essentially consisting of one or more hydrophilic pH independent polymers; wherein: the at least one disintegrating agent is present in amounts of 1-20% byweight and the at least one active principle is present in amounts of 1-80% by weight, with respect to the core; the sealing layer accounts for 0.1-10% byweight, withrespect to the core; the outer coating accounts for 5-500 % byweight, withrespect to the core. These coated cores are capable of ensuring the immediate release of the active principle after a pre-defined lag time, independently of physiological pH variations occurring in the gastro-intestinal tract of mammals.
Time-specific delayed/pulsatile release dosage forms / M. Cerea, S. De Luigi Bruschi, M.E. Sangalli, L. Zema, A. Gazzaniga.
Time-specific delayed/pulsatile release dosage forms
M. CereaPrimo
;M.E. Sangalli;L. ZemaPenultimo
;A. GazzanigaUltimo
2008
Abstract
A time specific delayed/pulsatile release dosage form which comprises: a core comprising at least one active principle and at least one disintegrating agent; a sealing layer surrounding the core essentially consisting of one or more water soluble or water insoluble pH independent polymers; an outer coating essentially consisting of one or more hydrophilic pH independent polymers; wherein: the at least one disintegrating agent is present in amounts of 1-20% byweight and the at least one active principle is present in amounts of 1-80% by weight, with respect to the core; the sealing layer accounts for 0.1-10% byweight, withrespect to the core; the outer coating accounts for 5-500 % byweight, withrespect to the core. These coated cores are capable of ensuring the immediate release of the active principle after a pre-defined lag time, independently of physiological pH variations occurring in the gastro-intestinal tract of mammals.Pubblicazioni consigliate
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