Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved in the bio-assembly of the nonribosomal peptide echinomycin. Putative intermediate peptide species were isolated and characterised, providing fresh insights into pathway substrate flexibility and paving the way for novel chemoenzymatic approaches towards unnatural peptides.
Novel chemical probes for the investigation of nonribosomal peptide assembly / Y.T.C. Ho, D.J. Leng, F. Ghiringhelli, I. Wilkening, D.P. Bushell, O. Köstner, E. Riva, J. Havemann, D. Passarella, M. Tosin. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 53:52(2017 Jun 27), pp. 7088-7091. [10.1039/C7CC02427D]
Novel chemical probes for the investigation of nonribosomal peptide assembly
D. PassarellaPenultimo
;
2017
Abstract
Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved in the bio-assembly of the nonribosomal peptide echinomycin. Putative intermediate peptide species were isolated and characterised, providing fresh insights into pathway substrate flexibility and paving the way for novel chemoenzymatic approaches towards unnatural peptides.
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