Resveratrol, a natural product with a stilbene structure, exerts profound proapoptotic activity in human cancer cells, by triggering the accumulation of ceramide, a bioactive sphingolipid. We studied the biological effects of seven methoxylated and/or naphthalene-based resveratrol analogues and compared these compounds with resveratrol with the objective to identify an analogue with higher ceramide-mediated proapoptotic activity relative to resveratrol. Here we show that the compound with three hydroxyls and a naphthalene ring is the most effective in triggering apoptosis coupled to the induction of endogenous ceramide in human cancer cells.

Synthesis of a resveratrol analogue with high ceramide-mediated proapoptotic activity on human breast cancer cells / F. Minutolo, G. Sala, A. Bagnacani, S. Bertini, I. Carboni, G. Placanica, G. Prota, S. Rapposelli, N. Sacchi, M. Macchia, R. Ghidoni. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - 48:22(2005), pp. 6783-6786.

Synthesis of a resveratrol analogue with high ceramide-mediated proapoptotic activity on human breast cancer cells

G. Sala;N. Sacchi;R. Ghidoni
2005

Abstract

Resveratrol, a natural product with a stilbene structure, exerts profound proapoptotic activity in human cancer cells, by triggering the accumulation of ceramide, a bioactive sphingolipid. We studied the biological effects of seven methoxylated and/or naphthalene-based resveratrol analogues and compared these compounds with resveratrol with the objective to identify an analogue with higher ceramide-mediated proapoptotic activity relative to resveratrol. Here we show that the compound with three hydroxyls and a naphthalene ring is the most effective in triggering apoptosis coupled to the induction of endogenous ceramide in human cancer cells.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/49365
Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 71
  • ???jsp.display-item.citation.isi??? 68
social impact