A new bioactive sesquiterpenoid, named dysidotronic acid 1, with a rearranged drimane skeleton has been isolated from the sponge Dysidea sp. from Vanuatu islands, along with bolinaquinone 2. The chemical structure of 1 was determined on the basis of spectroscopic data. Dysidotronic acid significantly inhibited human synovial phospholipase A2 (PLA2) at 10 μM, with an IC50 value of 2.6 μM and a higher selectivity and potency towards this enzyme than the reference inhibitor manoalide.
Dysidotronic acid, a new and selective human phospholipase A2 inhibitor from the sponge Dysidea sp / C. Giannini, C. Debitus, I. Posadas, M. Payá, M. V. D’Auria. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 41:17(2000), pp. 3257-3260.
Dysidotronic acid, a new and selective human phospholipase A2 inhibitor from the sponge Dysidea sp.
C. Giannini;
2000
Abstract
A new bioactive sesquiterpenoid, named dysidotronic acid 1, with a rearranged drimane skeleton has been isolated from the sponge Dysidea sp. from Vanuatu islands, along with bolinaquinone 2. The chemical structure of 1 was determined on the basis of spectroscopic data. Dysidotronic acid significantly inhibited human synovial phospholipase A2 (PLA2) at 10 μM, with an IC50 value of 2.6 μM and a higher selectivity and potency towards this enzyme than the reference inhibitor manoalide.
| File | Dimensione | Formato | |
|---|---|---|---|
|
1-s2.0-S0040403900003622-main.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
133.4 kB
Formato
Adobe PDF
|
133.4 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
