Seven new cytotoxic dimeric steroids, namely crellastatins B-H (2-8), have been isolated from the Vanuatu sponge Crella sp. They have been structurally characterized on the basis of 2D-NMR (500 MHz) and FAB-MS data. All the new compounds show the same unprecedented junction between the monomeric units, formed via their side-chains, whereas they differ from A (1) in the hydroxylation pattern of the two tetracyclic cores. Like crellastatin A (1), crellastatins B-H (2-8) exhibit in vitro antitumor activity against human bronchopulmonary non-small-cell lung carcinoma cell lines (NSCLC) with IC50 values in the range of 2-10 μg/mL.
Isolation and structural elucidation of crellastatins B-H : Cytotoxic bis(steroid) derivatives from the Vanuatu marine sponge Crella sp / A. Zampella, C. Giannini, C. Debitus, C. Roussakis, M.V. D'Auria. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - 1999:4(1999), pp. 949-953. [10.1002/(SICI)1099-0690(199904)1999:4<949::AID-EJOC949>3.0.CO;2-S]
Isolation and structural elucidation of crellastatins B-H : Cytotoxic bis(steroid) derivatives from the Vanuatu marine sponge Crella sp
C. GianniniSecondo
;
1999
Abstract
Seven new cytotoxic dimeric steroids, namely crellastatins B-H (2-8), have been isolated from the Vanuatu sponge Crella sp. They have been structurally characterized on the basis of 2D-NMR (500 MHz) and FAB-MS data. All the new compounds show the same unprecedented junction between the monomeric units, formed via their side-chains, whereas they differ from A (1) in the hydroxylation pattern of the two tetracyclic cores. Like crellastatin A (1), crellastatins B-H (2-8) exhibit in vitro antitumor activity against human bronchopulmonary non-small-cell lung carcinoma cell lines (NSCLC) with IC50 values in the range of 2-10 μg/mL.File | Dimensione | Formato | |
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