A new nonsymmetric dimeric steroid, crellastatin A (1), was isolated from the Vanuatu Island marine sponge Crella sp. Structural assignment was accomplished through extensive 2D NMR spectroscopy. The stereochemistry of 1 was established from an analysis of ROESY experiments and from molecular mechanics and dynamics calculations. Crellastatin A (1), which possesses an unprecedented connection through the side chains, exhibits in vitro cytotoxic activity against NSCLC-N6 cells (IC(50) of 1.5 &mgr;g/mL).
|Titolo:||Crellastatin A : a Cytotoxic Bis-Steroid Sulfate from the Vanuatu Marine Sponge Crella sp.|
GIANNINI, CLELIA (Secondo)
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
|Data di pubblicazione:||1998|
|Digital Object Identifier (DOI):||10.1021/jo981022v|
|Appare nelle tipologie:||01 - Articolo su periodico|