Helical oligomers of achiral monomers adopt domains of uniform screw sense, which are occasionally interrupted by screw-sense reversals. These rare, elusive, and fast-moving features have eluded detailed characterization. We now describe the structure and habits of a screw-sense reversal trapped within a fragment of a helical oligoamide foldamer of the achiral quaternary amino acid 2-aminoisobutyric acid (Aib). The reversal was enforced by compelling the amide oligomer to adopt a right-handed screw sense at one end and a left-handed screw sense at the other. The trapped reversal was characterized by X-ray crystallography, and its dynamic properties were monitored by NMR and circular dichroism, and modelled computationally. Raman spectroscopy indicated that a predominantly helical architecture was maintained despite the reversal. NMR and computational results indicated a stepwise shift from one screw sense to another on moving along the helical chain, indicating that in solution the reversal is not localised at a specific location, but is free to migrate across a number of residues. Analogous unconstrained screw-sense reversals that are free to move within a helical structure are likely to provide the mechanism by which comparable helical polymers and foldamers undergo screw-sense inversion.
A tendril perversion in a helical oligomer : trapping and characterizing a mobile screw-sense reversal / M. Tomsett, I. Maffucci, B.A.F. Le Bailly, L. Byrne, S.M. Bijvoets, M.G. Lizio, J. Raftery, C.P. Butts, S.J. Webb, A. Contini, J. Clayden. - In: CHEMICAL SCIENCE. - ISSN 2041-6520. - 8:4(2017 Jan 25), pp. 3007-3018.
|Titolo:||A tendril perversion in a helical oligomer : trapping and characterizing a mobile screw-sense reversal|
MAFFUCCI, IRENE (Secondo)
CONTINI, ALESSANDRO (Penultimo)
|Parole Chiave:||peptide folding; NMR; replica exchange molecular dynamics; non-natural amino acids|
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
|Data di pubblicazione:||25-gen-2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1039/C6SC05474A|
|Appare nelle tipologie:||01 - Articolo su periodico|