The central nervous system is a very challenging HIV-1 sanctuary. But, despite complete suppression of plasmatic viral replication with current antiretroviral therapy, signs of HIV-1 replication can still be found in the cerebrospinal fluid in some patients. The main limitation to achieving HIV-1 eradication from the brain is related to the suboptimal concentrations of antiretrovirals within this site, due to their low permeation across the blood–brain barrier. In recent years, a number of reliable nanotechnological strategies have been developed with the aim of enhancing antiretroviral drug penetration across the blood–brain barrier. The aim of this review is to provide an overview of the different nanoformulated antiretrovirals, used in both clinical and preclinical studies, that are designed to improve their delivery into the brain by active or passive permeation mechanisms through the barrier. Different nanotechnological approaches have proven successful for optimizing antiretrovirals delivery to the central nervous system, with a likely benefit for HIV-associated neurocognitive disorders and a more debated contribution to the complete eradication of the HIV-1 infection.
Nanoformulated Antiretrovirals for Penetration of the Central Nervous System: State of the Art / L. Fiandra, A. Capetti, L. Sorrentino, F. Corsi. - In: JOURNAL OF NEUROIMMUNE PHARMACOLOGY. - ISSN 1557-1890. - 12:1(2017), pp. 17-30.
|Titolo:||Nanoformulated Antiretrovirals for Penetration of the Central Nervous System: State of the Art|
FIANDRA, LUISA (Primo)
CAPETTI, AMEDEO FERDINANDO (Secondo)
SORRENTINO, LUCA (Penultimo)
CORSI, FABIO RUGGERO MARIA (Ultimo)
|Parole Chiave:||Antiretrovirals; Blood–brain barrier; Central nervous system; HIV; Nanotechnology; NeuroAIDS; Neuroscience (miscellaneous); Immunology and Allergy; Immunology; Pharmacology|
|Settore Scientifico Disciplinare:||Settore BIO/13 - Biologia Applicata|
Settore MED/17 - Malattie Infettive
|Data di pubblicazione:||2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s11481-016-9716-3|
|Appare nelle tipologie:||01 - Articolo su periodico|