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EnglishThe trimeric transcription factor NF-Y binds to the CCAAT box, an element enriched in promoters of genes overexpressed in tumors. Previous studies on the NF-Y regulome identified the general term metabolism as significantly enriched. We dissect here in detail the targeting of metabolic genes by integrating analysis of NF-Y genomic binding and profilings after inactivation of NF-Y subunits in different cell types. NF-Y controls de novo biosynthetic pathways of lipids, teaming up with the master SREBPs regulators. It activates glycolytic genes, but, surprisingly, is neutral or represses mitochondrial respiratory genes. NF-Y targets the SOCG (Serine, One Carbon, Glycine) and Glutamine pathways, as well as genes involved in the biosynthesis of polyamines and purines. Specific cancer-driving nodes are generally under NF-Y control. Altogether, these data delineate a coherent strategy to promote expression of metabolic genes fuelling anaerobic energy production and other anabolic pathways commonly altered in cancer cells.
NF-Y activates genes of metabolic pathways altered in cancer cells / P. Benatti, M.L. Chiaramonte, M. Lorenzo, J.A. Hartley, D. Hochhauser, N. Gnesutta, R. Mantovani, C. Imbriano, D. Dolfini. - In: ONCOTARGET. - ISSN 1949-2553. - 7:2(2016 Jan 12), pp. 1633-1650.
| Titolo: | NF-Y activates genes of metabolic pathways altered in cancer cells |
| Autori: | CHIARAMONTE, MARIA LUISA (Secondo) DOLFINI, DILETTA (Corresponding) |
| Parole Chiave: | cancer metabolism; glycolysis; NF-Y; SOCG pathway; transcription; CCAAT-binding factor; cell line, tumor; gene expression profiling; HCT116 cells; HeLa cells; humans; immunoblotting; K562 cells; metabolic networks and pathways; models, genetic; neoplasms; oligonucleotide array sequence analysis; reverse transcriptase polymerase chain reaction; gene expression regulation, neoplastic; RNA interference; oncology |
| Settore Scientifico Disciplinare: | Settore BIO/18 - Genetica |
| Data di pubblicazione: | 12-gen-2016 |
| Rivista: | |
| Tipologia: | Article (author) |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.18632/oncotarget.6453 |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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