We describe the case of a young HIV-positive man on effective HAART with excellent viro-immunological control who presented a massive cardiac infarction. Despite the presence of clinical risk factors for cardiovascular disease, the patient had normal arterial carotid IMT values, known to be strong predictors of atherosclerosis and stroke. Interestingly, parameters of T-cell activation (CD8+CD38+) were shown to increase just before the onset of myocardial infarction. As T-cell activation is known to mediate atherosclerosis, the authors suggest that surrogate immunologic markers should be identified to better assess cardiovascular risk in the setting of HIV infection.

Sudden cardiac death in a young HIV-positive man on effective antiretroviral therapy / C. Tincati, D. Bauer, G.M. Bellistrì, M. Casana, R. Ranieri, T. Bini, G. Marchetti, A. d'Arminio Monforte. - In: CURRENT HIV RESEARCH. - ISSN 1570-162X. - 6:6(2008), pp. 560-562.

Sudden cardiac death in a young HIV-positive man on effective antiretroviral therapy

C. Tincati;D. Bauer;G.M. Bellistrì;M. Casana;G. Marchetti;A. d'Arminio Monforte
2008

Abstract

We describe the case of a young HIV-positive man on effective HAART with excellent viro-immunological control who presented a massive cardiac infarction. Despite the presence of clinical risk factors for cardiovascular disease, the patient had normal arterial carotid IMT values, known to be strong predictors of atherosclerosis and stroke. Interestingly, parameters of T-cell activation (CD8+CD38+) were shown to increase just before the onset of myocardial infarction. As T-cell activation is known to mediate atherosclerosis, the authors suggest that surrogate immunologic markers should be identified to better assess cardiovascular risk in the setting of HIV infection.
Atherosclerosis; cardiovascular risk; HAART; immune activation; intima media thickness
Settore MED/17 - Malattie Infettive
Settore MED/08 - Anatomia Patologica
CURRENT HIV RESEARCH
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/47144
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