Thanks to their unique properties, as intrinsic conductivity and simple preparation, conducting polymers are highly applicable in tissue engineering, regenerative medicine, and biosensors. Pristine polymers often include residual precursors or other low molecular impurities, which have a negative impact on their biocompatibility. Concerning poly(4-aminodiphenylaniline), its cytotoxicity and biocompatibility have not yet been investigated. Herein, the cytotoxicity of poly(4-aminodiphenylaniline), prepared by an innovative green approach, as well as the effect of samples’ posttreatment and kind of dopant acid used, are reported for the first time. The results show that not only the type of used dopant but also polymers’ washing in phosphate saline buffer and material’s morphology has a significant impact on materials’ cytotoxicity. After a proper posttreatment or when salicylic acid is used as the doping agent the cytotoxicity of poly(4-aminodiphenylaniline) seem to be lower than those obtained for traditional PANI.

On the cytotoxicity of poly(4-aminodiphenylaniline) powders : effect of acid dopant type and sample post-treatment / C. Della Pina, Z. Kuceková, A. Sironi, P. Humpolíček, P. Sáha, E. Falletta. - In: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS. - ISSN 0091-4037. - 66:3(2017), pp. 132-138. [10.1080/00914037.2016.1190928]

On the cytotoxicity of poly(4-aminodiphenylaniline) powders : effect of acid dopant type and sample post-treatment

C. Della Pina;A. Sironi;E. Falletta
2017

Abstract

Thanks to their unique properties, as intrinsic conductivity and simple preparation, conducting polymers are highly applicable in tissue engineering, regenerative medicine, and biosensors. Pristine polymers often include residual precursors or other low molecular impurities, which have a negative impact on their biocompatibility. Concerning poly(4-aminodiphenylaniline), its cytotoxicity and biocompatibility have not yet been investigated. Herein, the cytotoxicity of poly(4-aminodiphenylaniline), prepared by an innovative green approach, as well as the effect of samples’ posttreatment and kind of dopant acid used, are reported for the first time. The results show that not only the type of used dopant but also polymers’ washing in phosphate saline buffer and material’s morphology has a significant impact on materials’ cytotoxicity. After a proper posttreatment or when salicylic acid is used as the doping agent the cytotoxicity of poly(4-aminodiphenylaniline) seem to be lower than those obtained for traditional PANI.
biocompatibility; cytotoxicity; dopant acid; Poly(4-aminodiphenylaniline)
Settore CHIM/03 - Chimica Generale e Inorganica
Settore CHIM/05 - Scienza e Tecnologia dei Materiali Polimerici
Magnetic-nanoparticle-filled conductive polymer composites for EMI reduction
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS
Article (author)
File in questo prodotto:
File Dimensione Formato  
Int.J. Polym. Mat Polym. Biomat_2016.pdf

non disponibili

Tipologia: Publisher's version/PDF
Dimensione 972.5 kB
Formato Adobe PDF
972.5 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/469030
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 3
social impact