Salmonella enterica serotype Napoli (S. Napoli) is currently emerging in Europe and particularly in Italy, where in 2014 it caused a large outbreak associated with elevated rates of bacteremia. However, no study has yet investigated its invasive ability and phylogenetic classification. Here, we show that between 2010 and 2014, S. Napoli was the first cause of invasive salmonellosis affecting 40 cases out of 687 (invasive index: 5.8%), which is significantly higher than the invasive index of all the other nontyphoidal serotypes (2.0%, p < 0.05). Genomic and phylogenetic analyses of an invasive isolate revealed that S. Napoli belongs to Typhi subclade in clade A, Paratyphi A being the most related serotype and carrying almost identical pattern of typhoid-associated genes. This work presents evidence of invasive capacity of S. Napoli and argues for reconsideration of its nontyphoidal category.

Salmonella enterica Serotype Napoli is the first cause of invasive nontyphoidal salmonellosis in Lombardy, Italy (2010-2014), and belongs to typhi subclade / P. Huedo, M. Gori, A. Zolin, E. Amato, G. Ciceri, A. Bossi, M. Pontello. - In: FOODBORNE PATHOGENS AND DISEASE. - ISSN 1535-3141. - 14:3(2017 Mar), pp. 148-151. [10.1089/fpd.2016.2206]

Salmonella enterica Serotype Napoli is the first cause of invasive nontyphoidal salmonellosis in Lombardy, Italy (2010-2014), and belongs to typhi subclade

M. Gori
Secondo
;
A. Zolin;E. Amato;G. Ciceri;A. Bossi
Penultimo
;
M. Pontello
Ultimo
2017

Abstract

Salmonella enterica serotype Napoli (S. Napoli) is currently emerging in Europe and particularly in Italy, where in 2014 it caused a large outbreak associated with elevated rates of bacteremia. However, no study has yet investigated its invasive ability and phylogenetic classification. Here, we show that between 2010 and 2014, S. Napoli was the first cause of invasive salmonellosis affecting 40 cases out of 687 (invasive index: 5.8%), which is significantly higher than the invasive index of all the other nontyphoidal serotypes (2.0%, p < 0.05). Genomic and phylogenetic analyses of an invasive isolate revealed that S. Napoli belongs to Typhi subclade in clade A, Paratyphi A being the most related serotype and carrying almost identical pattern of typhoid-associated genes. This work presents evidence of invasive capacity of S. Napoli and argues for reconsideration of its nontyphoidal category.
Salmonella Napoli; Salmonella Typhi; bacteremia; invasive salmonellosis; phylogeny
Settore MED/42 - Igiene Generale e Applicata
Settore MED/07 - Microbiologia e Microbiologia Clinica
mar-2017
16-dic-2016
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/468969
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