Bronchiectasis (BE) is a heterogeneous disease. Similarly, to other chronic airway diseases, such as asthma and chronic obstructive pulmonary disease, management of BE patients requires a specific and personalized treatment that depends on many clinical, functional, and microbiological variables. Therefore, developing phenotyping methods that can help clinical and therapeutic choices is of paramount importance. Various methodological approaches have been used to personalize patients' management. In this review, we explore the main tools identified so far to classify and phenotype BE patients, including the approaches based on BE etiologies, disease severity, cluster analysis, and endotyping. We also discuss the strengths and limitations of every approach and highlight the similarities and differences between these studies. Finally, we review the therapeutic implications and clinical management connected with each approach.

Phenotyping in bronchiectasis: are we moving toward a personalized medicine? / S. Aliberti, P. Faverio, S. Zucchetti, E. Simonetta, F. Amati, A. Gramegna, G. Sotgiu, F. Blasi, A. De Soyza. - In: COMMUNITY ACQUIRED INFECTIONS. - ISSN 2225-6482. - 3:4(2016), pp. 96-103. [10.4103/2225-6482.198488]

Phenotyping in bronchiectasis: are we moving toward a personalized medicine?

S. Aliberti
Primo
;
F. Amati;A. Gramegna;F. Blasi
Penultimo
;
2016

Abstract

Bronchiectasis (BE) is a heterogeneous disease. Similarly, to other chronic airway diseases, such as asthma and chronic obstructive pulmonary disease, management of BE patients requires a specific and personalized treatment that depends on many clinical, functional, and microbiological variables. Therefore, developing phenotyping methods that can help clinical and therapeutic choices is of paramount importance. Various methodological approaches have been used to personalize patients' management. In this review, we explore the main tools identified so far to classify and phenotype BE patients, including the approaches based on BE etiologies, disease severity, cluster analysis, and endotyping. We also discuss the strengths and limitations of every approach and highlight the similarities and differences between these studies. Finally, we review the therapeutic implications and clinical management connected with each approach.
Bronchiectasis, etiology, severity, inhaled antibiotics, phenotyping
Settore MED/10 - Malattie dell'Apparato Respiratorio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/468316
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