AIM: To predict the development of metachronous colorectal adenomas. METHODS: We analyze the cell kinetics of colorectal adenomas by autoradiographic method with tritiated thymidine and immunohistochemical detection with anti-PCNA antibodies. 46 patients who underwent prior endoscopic polypectomy for colorectal adenomas were re-evaluated by colonoscopy every six months for four years. RESULTS: Thymidine Labeling Index (T-LI) ranged from 1.4% to 38.0% with a median value of 10.45%; PCNA Labeling Index (PCNA-LI) ranged from 0% to 27.0% with a median value of 2.55%. Among the 46 patients studied, 16 developed recurrent adenomas (group A) and 30 were free of recurrent adenomas (group B). The median T-LI in group A and in group B were respectively 15.3% and 9%. The median PCNA-LI in group A and in group B were respectively 5.1% and 1.4%. Both labeling indices resulted significant risk factors in predicting adenoma recurrence. CONCLUSIONS: T-LI and PCNA-LI in colorectal adenomas are helpful in the prediction of the possibility of the development of a metachronous adenoma.
The prognostic value of cell proliferation in colorectal adenomas assessed with tritiated thymidine and anti-PCNA antibody / A.M. Lavezzi, G. Ottaviani, F. De Ruberto, G. Fichera, L. Matturri. - In: CANCER DETECTION AND PREVENTION. - ISSN 0361-090X. - 20:5(1996 Oct), pp. 519-519. ((Intervento presentato al 4. convegno International Symposium of International Society for Preventive Oncology (ISPO) tenutosi a Nice nel 1996.
The prognostic value of cell proliferation in colorectal adenomas assessed with tritiated thymidine and anti-PCNA antibody
A.M. Lavezzi
Primo
;G. OttavianiSecondo
;G. FicheraPenultimo
;L. MatturriUltimo
1996
Abstract
AIM: To predict the development of metachronous colorectal adenomas. METHODS: We analyze the cell kinetics of colorectal adenomas by autoradiographic method with tritiated thymidine and immunohistochemical detection with anti-PCNA antibodies. 46 patients who underwent prior endoscopic polypectomy for colorectal adenomas were re-evaluated by colonoscopy every six months for four years. RESULTS: Thymidine Labeling Index (T-LI) ranged from 1.4% to 38.0% with a median value of 10.45%; PCNA Labeling Index (PCNA-LI) ranged from 0% to 27.0% with a median value of 2.55%. Among the 46 patients studied, 16 developed recurrent adenomas (group A) and 30 were free of recurrent adenomas (group B). The median T-LI in group A and in group B were respectively 15.3% and 9%. The median PCNA-LI in group A and in group B were respectively 5.1% and 1.4%. Both labeling indices resulted significant risk factors in predicting adenoma recurrence. CONCLUSIONS: T-LI and PCNA-LI in colorectal adenomas are helpful in the prediction of the possibility of the development of a metachronous adenoma.File | Dimensione | Formato | |
---|---|---|---|
04_CDP_96_web_.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
117.8 kB
Formato
Adobe PDF
|
117.8 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.