Ionic liquids derived from active pharmaceutical ingredients may open new perspectives towards low-cost rescuing of classical drugs. Thus, we have synthesized novel ionic liquids derived from the antimalarial drug primaquine, and evaluated them in vitro against three stages of malaria parasites. Results from this unprecedented approach open a new chapter in the history of antimalarial drugs.
Primaquine-based ionic liquids as a novel class of antimalarial hits / R. Ferraz, J. Noronha, F. Murtinheira, F. Nogueira, M. Machado, M. Prudêncio, S. Parapini, S. D'Alessandro, C. Teixeira, A. Gomes, C. Prudêncio, P. Gomes. - In: RSC ADVANCES. - ISSN 2046-2069. - 6:61(2016 Jun 06), pp. 56134-56138.
Primaquine-based ionic liquids as a novel class of antimalarial hits
S. Parapini;S. D'Alessandro;
2016
Abstract
Ionic liquids derived from active pharmaceutical ingredients may open new perspectives towards low-cost rescuing of classical drugs. Thus, we have synthesized novel ionic liquids derived from the antimalarial drug primaquine, and evaluated them in vitro against three stages of malaria parasites. Results from this unprecedented approach open a new chapter in the history of antimalarial drugs.
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