Patients with inefficient CD4+ T-cell recovery on virogically suppressive highly active antiretroviral therapy constitute a major clinical hurdle given the threat of HIV/AIDS disease progression. We show heightened circulating lipopolysaccharide associated with plasma enterobacterial DNA and highly activated Ki67+CD4+CD8+ in 24 immunologic-nonresponders (CD4+ T-cell < or = 200; HIV-RNA < or = 50) compared with 11 full responders (CD4+ T-cell > or= 400; HIV-RNA < or = 50). These data provide novel insight into INRs pathogenesis, since they correlate augmented systemic translocation of microbial bioproducts with T-cell hyperactivation.
Titolo: | Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy |
Autori: | BELLISTRI', GIUSI MARIA (Secondo) D'ARMINIO MONFORTE, ANTONELLA (Ultimo) |
Parole Chiave: | bacterial translocation; activation; pathogenesis; individuals; trurnover; recovery; disease; cohort; haart; count |
Settore Scientifico Disciplinare: | Settore MED/17 - Malattie Infettive Settore MED/07 - Microbiologia e Microbiologia Clinica |
Data di pubblicazione: | 1-ott-2008 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | 10.1097/QAD.0b013e3283112d29 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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