Exogenous long-chain n-3 polyunsaturated fatty acids (LC-FA) are mainly incorporated into phospholipids in membranes and to some extent into cholesteryl esters. Limited data have been reported on the relative distribution of n-3 FA in lipoproteins. In the present study, fingertip blood and plasma levels of n-3 fatty acids, both at steady state or after a large intake (12 g of LC-FA as ethyl esters) were correlated to the levels of the major lipoproteins. At steady state there were weak, mainly non-significant correlations between n-3 levels and lipoproteins. However, the correlations became significantly negative between HDL-C levels and peak levels of n-3 or area under the curve after a single large intake of n-3 ethyl esters. These findings may shed light on recent observations indicating that exposure to n-3 can significantly decrease apoA-I, ABCA1, lecithin cholesterol acyltransferase and phospholipid transfer protein mRNA levels and antagonise A-I promoter activity.
Correlations of n-3 (omega-3) fatty acid levels with lipoproteins : negative correlation with HDL-C after an oral load / F. Maggi, C.R. Sirtori, D. Baldassarre, P. Risè, C. Galli. - In: NUTRAFOODS. - ISSN 1827-8590. - 12:1(2013), pp. 13-16.
|Titolo:||Correlations of n-3 (omega-3) fatty acid levels with lipoproteins : negative correlation with HDL-C after an oral load|
MAGGI, FRANCO (Primo)
RISE', PATRIZIA TIZIANA (Penultimo)
GALLI, CLAUDIO (Ultimo)
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||2013|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s13749-012-0067-2|
|Appare nelle tipologie:||01 - Articolo su periodico|