Objective: To test the hypothesis that a quantitative defect of maternal cellular mitochondria would play a role in the pathogenesis of HELLP syndrome. Study design: Peripheral blood mitochondrial DNA (MtDNA) was measured in 20 non-pregnant women with a history of HELLP syndrome, 40 non-pregnant control subjects who had previous physiologic pregnancies, 59 subjects carrying physiologic pregnancies, seven pregnant women with a history of HELLP syndrome and five women in the active phase of the disease. Main outcome measure: Peripheral blood Mt-DNA. Results: The median (interquartile range) mtDNA in women with a history of HELLP syndrome, in non-pregnant women who had previous physiologic pregnancies, in subjects carrying physiologic pregnancies, in pregnant women with a history of HELLP syndrome and in women in the active phase of the disease was 115 (81-194), 229 (199-319), 174 (136-211), 101 (82-178) and 92 (39-129) copies per nuclear DNA, respectively. Non-pregnant women with a history of HELLP syndrome had significantly lower levels than non-pregnant controls (p < 0.001). Moreover, blood mtDNA was lower in pregnant women with a history of HELLP syndrome and in those in the active phase of the disease when compared to pregnant controls (p = 0.002 and p = 0.025, respectively). Conclusions: Attenuated maternal mitochondrial function may favor HELLP syndrome development.
Depleted mitochondrial DNA content in peripheral blood of women with a history of HELLP syndrome / D. Lattuada, F. Crovetto, L. Trespidi, S. Mangano, B. Acaia, E. Somigliana, L. Fedele, G. Bolis. - In: PREGNANCY HYPERTENSION. - ISSN 2210-7789. - 3:3(2013), pp. 155-160.
|Titolo:||Depleted mitochondrial DNA content in peripheral blood of women with a history of HELLP syndrome|
LATTUADA, DEBORA FRANCESCA (Primo)
CROVETTO, FRANCESCA (Secondo)
SOMIGLIANA, EDGARDO (Corresponding)
FEDELE, LUIGI (Penultimo)
BOLIS, GIORGIO (Ultimo)
|Parole Chiave:||HELLP syndrome; Mitochondria; Pregnancy; Obstetrics and Gynecology; Internal Medicine|
|Settore Scientifico Disciplinare:||Settore MED/40 - Ginecologia e Ostetricia|
|Data di pubblicazione:||2013|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.preghy.2013.01.008|
|Appare nelle tipologie:||01 - Articolo su periodico|