TIR8 (also known as SIGIRR) is a member of the interleukin-1/Toll-like receptor family with inhibitory activity on inflammatory reactions and high expression in intestinal mucosa. Here, we report that Tir8-deficient mice exhibited a dramatic intestinal inflammation in response to dextran sulfate sodium salt (DSS) administration in terms of weight loss, intestinal bleeding, and mortality and showed increased susceptibility to carcinogenesis in response to azoxymethane and DSS. Increased susceptibility to colitis-associated cancer was associated to increased permeability and local production of prostaglandin E2, proinflammatory cytokines, and chemokines. Thus, these results are consistent with the hypothesis that TIR8, by negatively regulating intestinal inflammation, plays a non redundant role in the control of the protumor activity of chronic inflammation in the gut.

Increased susceptibility to colitis-associated cancer of mice lacking TIR8, an inhibitory member of the IL-1 receptor family / F. Riva, C. Garlanda, T. Veliz, N. Polentarutti, F. Pasqualini, E. Radaelli, M. Sironi, M. Nebuloni, E. Scanziani, A. Mantovani. ((Intervento presentato al convegno Inflammation and Cancer: from molecular links to bed side tenutosi a Rozzano nel 2007.

Increased susceptibility to colitis-associated cancer of mice lacking TIR8, an inhibitory member of the IL-1 receptor family

F. Riva
Primo
;
F. Pasqualini;E. Radaelli;M. Nebuloni;E. Scanziani
Penultimo
;
A. Mantovani
Ultimo
2007

Abstract

TIR8 (also known as SIGIRR) is a member of the interleukin-1/Toll-like receptor family with inhibitory activity on inflammatory reactions and high expression in intestinal mucosa. Here, we report that Tir8-deficient mice exhibited a dramatic intestinal inflammation in response to dextran sulfate sodium salt (DSS) administration in terms of weight loss, intestinal bleeding, and mortality and showed increased susceptibility to carcinogenesis in response to azoxymethane and DSS. Increased susceptibility to colitis-associated cancer was associated to increased permeability and local production of prostaglandin E2, proinflammatory cytokines, and chemokines. Thus, these results are consistent with the hypothesis that TIR8, by negatively regulating intestinal inflammation, plays a non redundant role in the control of the protumor activity of chronic inflammation in the gut.
8-nov-2007
Settore VET/05 - Malattie Infettive degli Animali Domestici
Increased susceptibility to colitis-associated cancer of mice lacking TIR8, an inhibitory member of the IL-1 receptor family / F. Riva, C. Garlanda, T. Veliz, N. Polentarutti, F. Pasqualini, E. Radaelli, M. Sironi, M. Nebuloni, E. Scanziani, A. Mantovani. ((Intervento presentato al convegno Inflammation and Cancer: from molecular links to bed side tenutosi a Rozzano nel 2007.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/452349
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