Our ancestors developed in environments characterized by salt scarcity; their salt intake was less than 1 g/day and efficient physiological mechanisms were evolved to retain salt. Nowadays, in many countries in the world, the current dietary salt intake is very high (10 g/day on average) and largely exceeds the recommended 5 g/day. Although not all studies agree, many evidences point to a relationship between high salt consumption, blood pressure, and its associated cardiovascular risk. Therefore, the adoption of a salt intake reduction is justified. Salt sensitivity, defined as blood pressure response to salt intake, is heterogeneous among subjects. Many authors have investigated the genetic bases of salt sensitivity, mainly with a candidate gene approach. Most of these findings need replication and much work is still necessary to identify the true genetic risk factors.

Dietary Salt Intake, Blood Pressure, and Genes / S. Lupoli, E. Salvi, C. Barlassina. - In: CURRENT NUTRITION REPORTS. - ISSN 2161-3311. - 2:3(2013 Sep), pp. 134-141. [10.1007/s13668-013-0047-1]

Dietary Salt Intake, Blood Pressure, and Genes

S. Lupoli;E. Salvi;C. Barlassina
2013-09

Abstract

Our ancestors developed in environments characterized by salt scarcity; their salt intake was less than 1 g/day and efficient physiological mechanisms were evolved to retain salt. Nowadays, in many countries in the world, the current dietary salt intake is very high (10 g/day on average) and largely exceeds the recommended 5 g/day. Although not all studies agree, many evidences point to a relationship between high salt consumption, blood pressure, and its associated cardiovascular risk. Therefore, the adoption of a salt intake reduction is justified. Salt sensitivity, defined as blood pressure response to salt intake, is heterogeneous among subjects. Many authors have investigated the genetic bases of salt sensitivity, mainly with a candidate gene approach. Most of these findings need replication and much work is still necessary to identify the true genetic risk factors.
Salt; Sodium; Diet; Cardiovascular risk; Salt-sensitivity; Prevention; Blood pressure; Hypertension; Genes Single nucleotide polymorphisms
Settore MED/14 - Nefrologia
Settore MED/03 - Genetica Medica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/447631
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