The aim of the present work was to estimate the risk of monochorionic twin (MCT) pregnancies in in vitro fertilization (IVF) cycles using data from a prenatal diagnosis unit. This was a retrospective cross-sectional study reporting on the frequency of IVF pregnancies among women attending a prenatal diagnosis service specifically dedicated to the management of monochorionic pregnancies. The observed rate was compared with the local regional rate of IVF births (2.2%). A binomial distribution model was used to calculate the 95% CI of proportions. One hundred and forty-five monochorionic pregnancies were selected. Ten of these were achieved with IVF, corresponding to a rate of 6.9% (95% CI: 3.5-11.8), significantly higher than the background rate in the local population of 2.2%. When considering exclusively monochorionic pregnancies achieving delivery of two viable newborns (n = 132), the number of IVF pregnancies was nine (6.8%, 95% CI: 3.7-12.5). We did not detect major differences in pregnancy outcome between IVF and natural monochorionic pregnancies, with the exception of the proportion of newborns with a neonatal birth < 2,500 g (100% vs. 80%, p =.03). In conclusion, data obtained from the perspective of a prenatal diagnosis unit suggest that women undergoing IVF face a 3-to 4-fold increased risk of monochorionic pregnancies.
Estimating the Risk of Monochorionic Twins in IVF Pregnancies from the Perspective of a Prenatal Diagnosis Unit / V. Sarais, A. Paffoni, G.M. Baffero, F. Parazzini, N. Persico, E. Somigliana. - In: TWIN RESEARCH AND HUMAN GENETICS. - ISSN 1832-4274. - 19:1(2016), pp. 66-71.
|Titolo:||Estimating the Risk of Monochorionic Twins in IVF Pregnancies from the Perspective of a Prenatal Diagnosis Unit|
SARAIS, VERONICA (Primo)
PAFFONI, ALESSIO (Corresponding)
SOMIGLIANA, EDGARDO (Ultimo)
|Parole Chiave:||in vitro fertilization; IVF; monochorionic; monozygotic; twin; genetics (clinical); obstetrics and gynecology; pediatrics, perinatology and child health|
|Settore Scientifico Disciplinare:||Settore MED/40 - Ginecologia e Ostetricia|
|Data di pubblicazione:||2016|
|Data ahead of print / Data di stampa:||22-dic-2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1017/thg.2015.94|
|Appare nelle tipologie:||01 - Articolo su periodico|