The immunosuppressive agents target of rapamycin inhibitors (TOR-I) (sirolimus, and everolimus) have been widely used in kidney transplantation for >10 years. Up to 40% of men receiving a kidney transplant are younger than 50, and fertility as well as erectile function are major concerns. In this review, we provide a synopsis of past studies focusing on gonadal function in men treated with TOR-I, mainly sirolimus, to establish what impact they have on male gonads, and which pathophysiological pathways are involved. A PubMed search for the years 1990-2006 selected articles that focused on the gonadal impact of TOR-I. Primary outcome measures were testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) levels. Secondary outcome measures were sexual function, fertility status and sperm parameters. Treatment with TOR-I results in a decrease in testosterone level, and an opposite increase in LH. Moreover, spermatogenesis seems to be disrupted by TOR-I and FSH levels are increased. Sirolimus and everolimus inhibit the activity of mammalian targets of rapamycin, a serine/threonine kinase involved in numerous cell-growth processes. Molecular mechanisms of action of TOR-I on the testis involve inhibition of a stem cell factor/c-kit-dependant process in spermatogonia. Preliminary results appear to show that TOR-I treatment has deleterious actions on the testis and impairs gonadal function after renal transplantation, but the impact of these effects are unknown.
Anti-hla antibodies profile retrospectively determined by luminex technique in lung transplant recipients : correlation with bos / E. Benazzi, A. Nocco, T. Oggionni, A. M. D'armini, M. Ravini, E. De Juli, A. Baisi, N. Stocchetti, M. Scalamogna. - In: TRANSPLANT INTERNATIONAL. - ISSN 0934-0874. - 20:2(2007 Sep), pp. 305-305. ((Intervento presentato al 13. convegno ESOT tenutosi a Praha nel 2007.
|Titolo:||Anti-hla antibodies profile retrospectively determined by luminex technique in lung transplant recipients : correlation with bos|
STOCCHETTI, NINO (Penultimo)
|Parole Chiave:||Erection; Everolimus; Fertility; Kidney transplantation; Male; Sirolimus; Testosterone|
|Settore Scientifico Disciplinare:||Settore MED/21 - Chirurgia Toracica|
|Data di pubblicazione:||set-2007|
|Enti collegati al convegno:||European Society for organ transplantation|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/j.1432-2277.2006.00423.x|
|Appare nelle tipologie:||01 - Articolo su periodico|