Oral lactoferrin supplementation in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-naïve children resulted in a skewing of T-lymphocytes towards more differentiated subpopulations. Phagocytosis (P = 0.01) and killing (P = 0.009), Toll-like receptor 2 expression (P = 0.01) and the interleukin-12/interleukin-10 ratio (P = 0.001) were also improved by lactoferrin. Lactoferrin supplementation results in immune modulation and could be useful in HIV infection.
Modulation of innate and adaptive immunity by lactoferrin in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-naïve children / G.V. Zuccotti, A. Viganò, M. Borelli, M. Sarasella, V. Giacomet, M. Clerici. - In: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. - ISSN 0924-8579. - 29:3(2007 Mar), pp. 353-355.
Modulation of innate and adaptive immunity by lactoferrin in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-naïve children
G.V. Zuccotti;M. Borelli;V. Giacomet;M. Clerici
2007
Abstract
Oral lactoferrin supplementation in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-naïve children resulted in a skewing of T-lymphocytes towards more differentiated subpopulations. Phagocytosis (P = 0.01) and killing (P = 0.009), Toll-like receptor 2 expression (P = 0.01) and the interleukin-12/interleukin-10 ratio (P = 0.001) were also improved by lactoferrin. Lactoferrin supplementation results in immune modulation and could be useful in HIV infection.
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