TheGENOMESUNCOUPLED1(GUN1)genehasbeenreportedtoencodeachloroplast-localizedpentatricopeptide-repeatprotein,whichactstointegratemultipleindicatorsofplastiddevelopmentalstageandalteredplastidfunction,aspartofchloroplast-to-nucleusretrogradecommunication.However,themolecularmechanismsunderlyingsignalintegrationbyGUN1haveremainedelusive,upuntiltherecentidentificationofasetofGUN1-interactingproteins,byco-immunoprecipitationandmass-spectrometricanalyses,aswellasprotein–proteininteractionassays.Here,wereviewthemolecularfunctionsofthedifferentGUN1partnersandproposeamajorroleforGUN1ascoordinatorofchloroplasttranslation,proteinimport,andproteindegradation.Thisregulatoryroleisimplementedthroughproteinsthat,inmostcases,arepartofmultimericproteincomplexesandwhoseprecisefunctionsvarydependingontheirassociationstates.Withinthisframework,GUN1mayactasaplatformtopromotespecificfunctionsbybringingtheinteractingenzymesintocloseproximitywiththeirsubstrates,ormayinhibitprocessesbysequesteringparticularpoolsofspecificinteractors.Furthermore,theinteractionsofGUN1withenzymesofthetetrapyrrolebiosynthesis(TPB)pathwaysupporttheinvolvementoftetrapyrrolesassignalingmoleculesinretrogradecommunication.
GUN1, a Jack-Of-All-Trades in Chloroplast Protein Homeostasis and Signaling / M. Colombo, L. Tadini, C. Peracchio, R. Ferrari, P. Pesaresi. - In: FRONTIERS IN PLANT SCIENCE. - ISSN 1664-462X. - 7(2016 Sep 22), pp. 1427.1-1427.14.
Titolo: | GUN1, a Jack-Of-All-Trades in Chloroplast Protein Homeostasis and Signaling |
Autori: | TADINI, LUCA (Secondo) FERRARI, ROBERTO (Penultimo) PESARESI, PAOLO (Ultimo) |
Parole Chiave: | nucleoid,GUN1,proteinhomeostasis,retrogradesignaling,biogeniccontrol |
Settore Scientifico Disciplinare: | Settore BIO/18 - Genetica Settore BIO/04 - Fisiologia Vegetale |
Progetto: | BarPLUS: modifying canopy architecture and photosynthesis to maximize barley biomass and yield for different end-uses |
Data di pubblicazione: | 22-set-2016 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.3389/fpls.2016.01427 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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