Self-assembly drug conjugate preparation is a promising approach to improve activity and penetration through physiological barriers of potent small molecules, as well as to reduce any side effects. Drug conjugates can self-assemble in water to form nanoparticles (NPs) that offer several advantages because: (i) they are easy to obtain; (ii) they can reach high local drug concentration in tumor tissues; and (iii) they can reduce the side effects of drugs. All these factors improve drug pharmacokinetic properties. Here, we have reviewed the scope of nanotechnology-based self-assembly drug delivery approaches focusing on prodrugs able to form NPs by self-assembly; we have also summarized the current perspective and challenges facing the successful treatment of cancer.
Self-assembly drug conjugates for anticancer treatment / G. Fumagalli, C. Marucci, B. Stella, F. Dosio, D. Passarella, M.S. Christodoulou. - In: DRUG DISCOVERY TODAY. - ISSN 1359-6446. - 21:8(2016 Aug 01), pp. 1321-1329.
|Titolo:||Self-assembly drug conjugates for anticancer treatment|
PASSARELLA, DANIELE (Corresponding)
|Parole Chiave:||pharmacology; drug discovery3003; pharmaceutical science|
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
Settore CHIM/08 - Chimica Farmaceutica
|Data di pubblicazione:||1-ago-2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.drudis.2016.06.018|
|Appare nelle tipologie:||01 - Articolo su periodico|