Self-assembly drug conjugate preparation is a promising approach to improve activity and penetration through physiological barriers of potent small molecules, as well as to reduce any side effects. Drug conjugates can self-assemble in water to form nanoparticles (NPs) that offer several advantages because: (i) they are easy to obtain; (ii) they can reach high local drug concentration in tumor tissues; and (iii) they can reduce the side effects of drugs. All these factors improve drug pharmacokinetic properties. Here, we have reviewed the scope of nanotechnology-based self-assembly drug delivery approaches focusing on prodrugs able to form NPs by self-assembly; we have also summarized the current perspective and challenges facing the successful treatment of cancer.

Self-assembly drug conjugates for anticancer treatment / G. Fumagalli, C. Marucci, B. Stella, F. Dosio, D. Passarella, M.S. Christodoulou. - In: DRUG DISCOVERY TODAY. - ISSN 1359-6446. - 21:8(2016 Aug 01), pp. 1321-1329.

Self-assembly drug conjugates for anticancer treatment

G. Fumagalli;C. Marucci;D. Passarella;M.S. Christodoulou
2016-08-01

Abstract

Self-assembly drug conjugate preparation is a promising approach to improve activity and penetration through physiological barriers of potent small molecules, as well as to reduce any side effects. Drug conjugates can self-assemble in water to form nanoparticles (NPs) that offer several advantages because: (i) they are easy to obtain; (ii) they can reach high local drug concentration in tumor tissues; and (iii) they can reduce the side effects of drugs. All these factors improve drug pharmacokinetic properties. Here, we have reviewed the scope of nanotechnology-based self-assembly drug delivery approaches focusing on prodrugs able to form NPs by self-assembly; we have also summarized the current perspective and challenges facing the successful treatment of cancer.
pharmacology; drug discovery3003; pharmaceutical science
Settore CHIM/06 - Chimica Organica
Settore CHIM/08 - Chimica Farmaceutica
DRUG DISCOVERY TODAY
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/437339
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