Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases, promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches.
|Titolo:||Cancer related inflammation : the macrophage connection|
|Autori interni:||MANTOVANI, ALBERTO (Ultimo)|
|Parole Chiave:||Angiogenesis; Cancer; Chemokines; Cytokines; Inflammation; Macrophage polarization; Therapeutic targets; Tumor promotion; Tumor-associated macrophages|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||28-ago-2008|
|Digital Object Identifier (DOI):||10.1016/j.canlet.2008.03.028|
|Appare nelle tipologie:||01 - Articolo su periodico|