Purpose To determine whether the analysis of the slow expiratory transpulmonary pressure–volume (PL-V) curve provides an alternative to the single-breath nitrogen test (SBN) for the assessment of the closing volume (CV). Methods SBN test and slow deflation PL-V curve were simultaneously recorded in 40 healthy subjects and 43 COPD patients. Onset of phase IV identified CV in SBN test (CVSBN), whereas in the PL-V curve CV was identified by: a) deviation from the exponential fit (CVexp), and b) inflection point of the interpolating sigmoid function (CVsig). Results In the absence of phase IV, COPD patients exhibited a clearly discernible inflection in the PL-V curve. In the presence of phase IV, CVSBN and CVexp coincided (CVSBN/CVexp = 1.04 ± 0.04 SD), whereas CVsig was systematically larger (CVsig/CVexp = 2.1 ± 0.86). Conclusion The coincidence between CVSBN and CVexp, and the presence of the inflection in the absence of phase IV indicate that the deviation of the PL-V curve from the exponential fit reliably assesses CV.

Airway occlusion assessed by single breath N2 test and lung P-V curve in healthy subjects and COPD patients / M. Pecchiari, D. Radovanovic, P. Santus, E. D'Angelo. - In: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY. - ISSN 1569-9048. - 234(2016 Dec), pp. 60-68. [10.1016/j.resp.2016.09.006]

Airway occlusion assessed by single breath N2 test and lung P-V curve in healthy subjects and COPD patients

M. Pecchiari;D. Radovanovic;P. Santus;E. D'Angelo
2016-12

Abstract

Purpose To determine whether the analysis of the slow expiratory transpulmonary pressure–volume (PL-V) curve provides an alternative to the single-breath nitrogen test (SBN) for the assessment of the closing volume (CV). Methods SBN test and slow deflation PL-V curve were simultaneously recorded in 40 healthy subjects and 43 COPD patients. Onset of phase IV identified CV in SBN test (CVSBN), whereas in the PL-V curve CV was identified by: a) deviation from the exponential fit (CVexp), and b) inflection point of the interpolating sigmoid function (CVsig). Results In the absence of phase IV, COPD patients exhibited a clearly discernible inflection in the PL-V curve. In the presence of phase IV, CVSBN and CVexp coincided (CVSBN/CVexp = 1.04 ± 0.04 SD), whereas CVsig was systematically larger (CVsig/CVexp = 2.1 ± 0.86). Conclusion The coincidence between CVSBN and CVexp, and the presence of the inflection in the absence of phase IV indicate that the deviation of the PL-V curve from the exponential fit reliably assesses CV.
airway resistance; closing volume; lung pressure-volume curve; phase IV; single breath nitrogen test; single breath oxygen test
Settore BIO/09 - Fisiologia
Settore MED/10 - Malattie dell'Apparato Respiratorio
6-set-2016
Article (author)
File in questo prodotto:
File Dimensione Formato  
Airway occlusion assessed by single breath N2 test and lung P-V curve in healthy subjects and COPD patients.pdf

non disponibili

Tipologia: Publisher's version/PDF
Dimensione 1.3 MB
Formato Adobe PDF
1.3 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
434872PP_Airway occlusion.pdf

accesso aperto

Tipologia: Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione 977.38 kB
Formato Adobe PDF
977.38 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/434872
Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 16
social impact