Context: Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis.Objective: Assess association of CgA levels and mortality risk of severely septic patients.Methods: Serum CgA levels were measured in 50 hospitalized, severely septic patients with organ failure <48 h.Results: Higher CgA levels trended toward higher ICU and hospital mortality. Patients without cardiovascular disease who died in the ICU had higher median (IQR) CgA levels 602.3 (343.3, 1134.3) ng/ml versus 205.5 (130.7, 325.9) ng/ml, p = 0.01.Conclusions: High CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.
Chromogranin A levels and mortality in patients with severe sepsis / C. Hsu, L.F. Reyes, C.J. Orihuela, R. Buitrago, A. Anzueto, N.J. Soni, S. Levine, J. Peters, C.A. Hinojosa, S. Aliberti, O. Sibila, A. Rodriguez, J.D. Chalmers, I. Martin Loeches, J. Bordon, J. Blanquer, F. Sanz, P.J. Marcos, J. Rello, J. Solé Violán, M.I. Restrepo. - In: BIOMARKERS. - ISSN 1354-750X. - 20:3(2015), pp. 171-176. [10.3109/1354750X.2015.1046932]
Chromogranin A levels and mortality in patients with severe sepsis
S. Aliberti;
2015
Abstract
Context: Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis.Objective: Assess association of CgA levels and mortality risk of severely septic patients.Methods: Serum CgA levels were measured in 50 hospitalized, severely septic patients with organ failure <48 h.Results: Higher CgA levels trended toward higher ICU and hospital mortality. Patients without cardiovascular disease who died in the ICU had higher median (IQR) CgA levels 602.3 (343.3, 1134.3) ng/ml versus 205.5 (130.7, 325.9) ng/ml, p = 0.01.Conclusions: High CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.
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