Chiral 1,3-substituted 1,2,3,4-tetrahydroisoquinolines have been synthesized in acceptable yield and diastereoselectivity through a three component reaction, starting from aromatic halides, enantiopure bromoalkyl derivatives and methyl acrylate, under palladium catalysis.
Stereoselective synthesis of 1,3-substituted tetrahydroisoquinolines through palladium-catalyzed three-component reaction / R. Ferraccioli, C. Giannini, G. Molteni. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 18:12(2007), pp. 1475-1480. [10.1016/j.tetasy.2007.05.031]
Stereoselective synthesis of 1,3-substituted tetrahydroisoquinolines through palladium-catalyzed three-component reaction
C. Giannini;G. Molteni
2007
Abstract
Chiral 1,3-substituted 1,2,3,4-tetrahydroisoquinolines have been synthesized in acceptable yield and diastereoselectivity through a three component reaction, starting from aromatic halides, enantiopure bromoalkyl derivatives and methyl acrylate, under palladium catalysis.
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