The spectrum of bleeding problems in FVII deficiency is highly variable and FVII levels and causative genetic mutations correlate poorly with the bleeding risk. Long-term prophylaxis is generally initiated in order to prevent subsequent CNS bleeding after a first event or in patients with other major/ life threatening/ frequent bleeding symptoms as gastrointestinal bleeding or hemarthrosis. However few data are available in the literature regarding FVII prophylaxis and clinical decisions cannot be based on evidence.
Long-term prophylaxis in severe factor VII deficiency / S.M. Siboni, E. Biguzzi, C. Mistretta, I. Garagiola, F. Peyvandi. - In: HAEMOPHILIA. - ISSN 1351-8216. - 21:6(2015 Nov), pp. 812-819. [10.1111/hae.12702]
Long-term prophylaxis in severe factor VII deficiency
C. Mistretta;I. GaragiolaPenultimo
;F. PeyvandiUltimo
2015
Abstract
The spectrum of bleeding problems in FVII deficiency is highly variable and FVII levels and causative genetic mutations correlate poorly with the bleeding risk. Long-term prophylaxis is generally initiated in order to prevent subsequent CNS bleeding after a first event or in patients with other major/ life threatening/ frequent bleeding symptoms as gastrointestinal bleeding or hemarthrosis. However few data are available in the literature regarding FVII prophylaxis and clinical decisions cannot be based on evidence.File | Dimensione | Formato | |
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Siboni SM, Haemophilia 2015 - prophylaxis in FVII def.pdf
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