The spectrum of bleeding problems in FVII deficiency is highly variable and FVII levels and causative genetic mutations correlate poorly with the bleeding risk. Long-term prophylaxis is generally initiated in order to prevent subsequent CNS bleeding after a first event or in patients with other major/ life threatening/ frequent bleeding symptoms as gastrointestinal bleeding or hemarthrosis. However few data are available in the literature regarding FVII prophylaxis and clinical decisions cannot be based on evidence.

Long-term prophylaxis in severe factor VII deficiency / S.M. Siboni, E. Biguzzi, C. Mistretta, I. Garagiola, F. Peyvandi. - In: HAEMOPHILIA. - ISSN 1351-8216. - 21:6(2015 Nov), pp. 812-819. [10.1111/hae.12702]

Long-term prophylaxis in severe factor VII deficiency

MISTRETTA, CLAUDIA;I. Garagiola;F. Peyvandi
2015-11

Abstract

The spectrum of bleeding problems in FVII deficiency is highly variable and FVII levels and causative genetic mutations correlate poorly with the bleeding risk. Long-term prophylaxis is generally initiated in order to prevent subsequent CNS bleeding after a first event or in patients with other major/ life threatening/ frequent bleeding symptoms as gastrointestinal bleeding or hemarthrosis. However few data are available in the literature regarding FVII prophylaxis and clinical decisions cannot be based on evidence.
factor VII deficiency; long-term prophylaxis; rare coagulation disorders; Adolescent; Adult; Child; Child, Preschool; Factor VII Deficiency; Factor VIIa; Female; Humans; Infant; Infant, Newborn; Male; Middle Aged; Mutation; Recombinant Proteins; Time Factors; Young Adult
Settore MED/09 - Medicina Interna
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/430041
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